It is a well known fact that both surgery and chemonucleolysis can cure a patient suffering from root pain due to a prolapsed intervertebral disc. However, the failure rate after intradiscal injection of chymopapain remains important. Analysis of the cases operated after unsuccessful chemonucleolysis show that about two thirds are due to a remaining discal fragment. Considering the possibility of a bad penetration of the enzyme in the herniated area, neither computed tomography (CT) scan nor myelography, but only discography, can demonstrate invasion of the prolapsed area. On a series of 165 patients injected with chymopapain in only one disc, discographic data were correlated with the result of the treatment on the root pain. Three items were analyzed: the size of the protruding area located at the back of the disc (closely related to operative findings, as shown on a previous study), the density of the contrast medium filling the protruding area, and the pain response during the injection. A large, well-filled protruding area characterizes a "good" image and correlated with 76% of good results. Likewise when the pain response is lateralized (in the buttock or the affected lower limb), it correlates with 42% of success and 13% of failures. In 24.8% of the cases a combination of good images and lateralized pain correlates with 97.5% of good results. Therefore discography should be an element of decision between surgery and chemonucleolysis, and should be considered as a preoperative examination.

Download full-text PDF

Source

Publication Analysis

Top Keywords

protruding area
12
discography element
8
element decision
8
decision surgery
8
surgery chemonucleolysis
8
root pain
8
pain response
8
pain
5
area
5
surgery versus
4

Similar Publications

The regeneration of endothelial cells (ECs) lining arteries, veins, and large lymphatic vessels plays an important role in vascular pathology. To understand the mechanisms of atherogenesis, it is important to determine what happens during endothelial regeneration. A comparison of these processes in the above-mentioned vessels reveals both similarities and some significant differences.

View Article and Find Full Text PDF

Fibrous Dysplasia of the Ethmoid Bone Diagnosed in a 10-Year-Old Patient.

Medicina (Kaunas)

December 2024

Department of Otolaryngology, Head and Neck Surgery, Wroclaw Medical University, 50-556 Wrocław, Poland.

Fibrous dysplasia is an uncommon bone disorder affecting various parts of the skeleton, often affecting facial and cranial bones. In this case, a 10-year-old patient was diagnosed with fibrous dysplasia of the ethmoid sinus at an early age. The patient has experienced nasal congestion, snores, and worsening nasal patency since 2019.

View Article and Find Full Text PDF

Cestodes of the genus Spirometra are multi-host parasites that are the causative agents of spirometrosis in domestic and wild carnivores and sparganosis in humans, endemic diseases in tropical and subtropical regions. In domestic animals, the infection is usually asymptomatic or produces gastrointestinal signs such as vomiting and chronic diarrhoea. In humans, an incidental parasitosis develops where the plerocercoid can lodge in tissues and cause a variety of symptoms, including neuropathies, blindness, paralysis, and death.

View Article and Find Full Text PDF

Quality of Life and Adaptation of People With a Colostomy Plug: A Before-After Interventional Study.

J Wound Ostomy Continence Nurs

January 2025

Iraktânia Vitorino Diniz, MSc, RN , Doctoral Student in Nursing at the Federal University of Paraiba, Campus I - Lot. City Universitaria, João Pessoa, Paraíba 58051-900, Brazil.

Purpose: The purpose of this study was to examine health-related quality of life and adaptation of persons with a colostomy before and after use of a colostomy plug.

Design: Single group before-and-after study.

Subjects And Setting: The study sample comprised 19 people with a colostomy who attended an outpatient clinic João Pessoa, in Paraiba, Brazil.

View Article and Find Full Text PDF

Left-Right Brain-Wide Asymmetry of Neuroanatomy in the Mouse Brain.

Neuroimage

January 2025

Department of Genetics, Harvard Medical School, Boston, MA, USA; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA. Electronic address:

Left-right asymmetry of the human brain is widespread through its anatomy and function. However, limited microscopic understanding of it exists, particularly for anatomical asymmetry where there are few well-established animal models. In humans, most brain regions show subtle, population-average regional asymmetries in thickness or surface area, alongside a macro-scale twisting called the cerebral petalia in which the right hemisphere protrudes past the left.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!