Intraoperative CT scanning is the international standard for treating midface fractures as it allows intraoperative assessment of reduction and fixation. To our knowledge, no NHS hospital in the UK has this facility yet due to the financial and logistical burden of its implementation. The aim of this study was to determine if complications including the requirement for a return to theatre (RTT) could have been predicted from the post-fixation CT scan. All treated midface fractures that had presented to a regionalised major trauma centre within two years (01 January 2020 - 31 December 2021) were identified. Those developing complications including RTT were determined. All postoperative CT scans (including those without complication or RTT) were re-analysed with the clinicians blinded to the outcomes to determine the positive predictive value (PPV) and negative predictive value (NPV) of requiring RTT to alter plate position intraoperatively based on CT scan alone. In all, there were eight episodes of unplanned return to theatre, resulting in an overall RTT rate of 8/119 (6.7%). When only analysing patients treated for orbital fractures this RTT rises to 8/40 (20%). Of those eight patients who had a postoperative CT and required RTT, this could have been predicted in 7/8 (87.5%). A total of 16/44 (36.4%) patients that did not have RTT would have additionally been recommended to have the plate position altered based on CT alone. Based upon those that had a CT, the PPV of CT alone being able to predict those requiring RTT was 40.6% and the NPV 96.2%. Our results would suggest intraoperative CT would likely have prevented eight patients requiring RTT in two years and could have improved outcomes in 16 cases. In preventing RTT as well as potentially improving the outcomes of a further 16 cases in maxillofacial surgery, the purchase of an intraoperative CT scanner could yield net savings of £75534-£114990 over two years.
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http://dx.doi.org/10.1016/j.bjoms.2023.03.010 | DOI Listing |
Biochem Cell Biol
January 2025
University of Victoria Faculty of Science, Biochemsitry and Microbiology, Victoria, British Columbia, Canada;
Methyl CpG binding protein 2 (MeCP2) is a chromatin-associated protein that remains enigmatic despite more than 30 years of research, primarily due to the ever-growing list of its molecular functions, and, consequently, its related pathologies. Loss of function MECP2 mutations cause the neurodevelopmental disorder Rett syndrome (RTT); in addition, dysregulation of MeCP2 expression and/or function are involved in numerous other pathologies, but the mechanisms of MeCP2 regulation are unclear. Advancing technologies and burgeoning mechanistic theories assist our understanding of the complexity of MeCP2 but may inadvertently cloud it if not rigorously tested.
View Article and Find Full Text PDFRadiography (Lond)
December 2024
Université Libre de Bruxelles (ULB), Brussels University Hospital, Jules Bordet Institute, Radiotherapy Department, Rue Meylemeersch 90, 1070 Bruxelles, Belgium.
Introduction: Radiation Therapists (RTTs) are crucial in delivering Radiotherapy (RT) to cancer patients. The advancements in RT technology and the increasing cancer incidence have heightened the demand for RTTs, necessitating strategic workforce planning at the national level. This study aims to identify and estimate current and future RTT workforce in Belgium.
View Article and Find Full Text PDFOrphanet J Rare Dis
December 2024
All Wales Medical Genomics Service, Wales Genomic Health Centre, Cardiff Edge Business Park, Longwood Drive, Whitchurch, Cardiff, CF14 7YU, Wales, UK.
Background: We have held a 'trouble-shooting' clinic for Rett syndrome patients from 2003 until the COVID pandemic in 2020. The clinic was multidisciplinary, including clinical genetics, paediatric neurology, adult learning disability psychiatry and physiotherapy. Access to specialist communication support and eye-gaze equipment was also often available.
View Article and Find Full Text PDFBMC Health Serv Res
December 2024
School of Nursing, Kamuzu University of Health Sciences, P/Bag 360, Chichiri, Blantyre 3, Malawi.
Background: Numerous studies report low diabetes knowledge among nurses in sub-Saharan Africa. However, little is known about the factors that hinder and promote their acquisition of knowledge on diabetes mellitus. Understanding these factors is a pivotal step towards ensuring that nurses are knowledgeable and competent in the provision of care and education for patients with diabetes mellitus.
View Article and Find Full Text PDFJ Radiat Res
December 2024
Department of Radiology, University of Yamanashi School of Medicine, 1110 Shimokato, Chuo-shi, Yamanashi 409-3898, Japan.
The current research on staffing models is primarily focused on conventional external photon beam therapy, which predominantly involves using linear accelerators. This emphasizes the need for comprehensive studies to understand better and define specific particle therapy facilities' staffing requirements. In a 2022 survey of 25 particle therapy facilities in Japan with an 84% response rate, significant insights were obtained regarding workload distribution, defined as the product of personnel count and task time (person-minutes), for patient-related tasks and equipment quality assurance and quality control (QA/QC).
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