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β-Catenin mediated TAM phenotype promotes pancreatic cancer metastasis via the OSM/STAT3/LOXL2 axis.
Neoplasia
December 2024
Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, PR China. Electronic address:
Pancreatic ductal adenocarcinoma (PDAC) is characterized by its aggressive nature and dismal prognosis, largely attributed to its unique tumor microenvironment. However, the molecular mechanisms by which tumor-associated macrophages (TAMs) promote PDAC progression, particularly the role of β-catenin signaling in regulating TAM phenotype and function, remain incompletely understood. Initially, we performed comprehensive analyses of RNA-seq and single-cell RNA-seq (scRNA-seq) datasets to investigate OSM and LOXL2 expression patterns in PDAC.
View Article and Find Full Text PDFHyperglycemia Inhibits AAA Expansion: Examining the Role of Lysyl Oxidase.
Am J Physiol Heart Circ Physiol
December 2024
B. Timothy Baxter, MD: University of Nebraska Medical Center, 68198 Nebraska Medicine, Omaha, Ne 68198-2500 (402-639-0144).
Abdominal aortic aneurysm (AAA) is a common, progressive and potentially fatal dilation of the most distal aortic segment. Multiple studies with longitudinal follow-up of AAA have identified markedly slower progression among patients affected with diabetes. Understanding the molecular pathway responsible for the growth inhibition could have implications for therapy in nondiabetic AAA patients.
View Article and Find Full Text PDFO-GlcNAcylation stabilized WTAP promotes GBM malignant progression in an N6-methyladenosine-dependent manner.
Neuro Oncol
December 2024
Department of Neurosurgery, Qilu Hospital of Shandong University, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan 250012, Shandong, China.
Background: Interactions between mesenchymal glioblastoma stem cells (MES GSCs) and myeloid-derived macrophages (MDMs) shape the tumor-immunosuppressive microenvironment (TIME), promoting the progression of glioblastoma (GBM). N6-methyladenosine (m6A) plays important roles in the tumor progression. However, the mechanism of m6A in shaping the TIME of GBM remains elusive.
View Article and Find Full Text PDFPrognostic significance of LOXL2 enzyme activity in primary myelofibrosis.
Medicine (Baltimore)
December 2024
School of Medicine, Pingdingshan University, Pingdingshan, China.
Primary myelofibrosis (PMF) is characterized by bone marrow fibrosis, but the underlying molecular mechanisms remain incompletely understood. Here, we investigated the role of lysyl oxidase-like 2 (LOXL2), an enzyme involved in extracellular matrix remodeling, in PMF pathogenesis. Analysis of bone marrow cells from PMF patients revealed significantly elevated LOXL2 mRNA expression compared to healthy controls, which was further validated using 2 independent Gene Expression Omnibus datasets (GSE26049 and GSE12234).
View Article and Find Full Text PDFOxidative stress gene signature construction to identify subtypes and prognosis of patients with lung adenocarcinoma.
Heliyon
October 2024
Department of Radiation Oncology, The Third Affiliated Hospital of Kunming Medical University/Yunnan Cancer Hospital/Peking University Cancer Hospital Yunnan, Kunming 650118, Yunnan, China.
Article Synopsis
- Researchers investigated how oxidative stress response-related genes (OSRGs) impact lung adenocarcinoma (LUAD) to create a genetic signature that could predict patient prognosis and suggest treatment options.
- They developed a risk prediction model using clinical data and various assay methods to analyze the relationship between gene expression and factors like immune cell infiltration and chemotherapy sensitivity.
- The study concluded that the identified gene signature could serve as a reliable biomarker for predicting patient outcomes and therapy responses in LUAD, with specific findings on the effects of DKK1 on cell behavior.
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