AI Article Synopsis
- LLPS is key for creating membraneless compartments in cells, leading to interest in how to control the condensation of biomolecules.
- Recent studies highlight the significant influence of metals and inorganic molecules, which are commonly found in cells, on regulating this condensation process.
- The review provides an overview of biomacromolecular phase separation and summarizes recent findings on how these substances affect the phase separation of proteins and nucleic acids both in lab settings and within living cells.
Article Abstract
The realization that liquid-liquid phase separation (LLPS) underlies the formation of membraneless compartments in cells has motivated efforts to modulate the condensation process of biomolecules. Increasing evidence shows that metals and inorganic molecules abundantly distributed in cells play important roles in the regulation of biomolecular condensation. Herein, we briefly reviewed the background of biomacromolecular phase separation and summarized the recent research progress on the roles of metals and inorganic molecules in regulating protein and nucleic acid phase separation in vitro and in cells.
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| http://dx.doi.org/10.1016/j.cbpa.2023.102308 | DOI Listing |
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