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Clinical impact of inappropriate DOAC dosing in atrial fibrillation: Insights from a real-world registry.
Int J Cardiol Heart Vasc
February 2025
Department of Internal Medicine III, Cardiology, University Hospital of Heidelberg, Germany.
Background: A significant number of patients with atrial fibrillation (AF) on direct oral anticoagulants (DOACs) receives off-label or inappropriate doses. This study examines the prevalence, dosages, and clinical outcomes in AF-patients on DOAC therapy admitted to an emergency department (ED).
Methods: This retrospective single-center observational study utilized data from the Heidelberg Registry of Atrial Fibrillation (HERA-FIB), consecutively including patients with AF presenting to the ED of the University Hospital of Heidelberg from June 2009 to March 2020.
Impact of Right Atrial Plication on Pulmonary Function and Heart Failure Symptoms: A Case Report.
Cureus
December 2024
Cardiovascular Surgery, IMS Katsushika Heart Center, Tokyo, JPN.
An 85-year-old woman with long-standing atrial fibrillation and severe tricuspid regurgitation presented with worsening symptoms and massive right atrial enlargement (RAE). The patient experienced shortness of breath even during minimal exertion, such as walking within her house, which significantly impacted her daily activities. Surgical intervention, including tricuspid valve replacement and right atrial plication (RAP), led to significant symptomatic relief and improved pulmonary function.
View Article and Find Full Text PDFDispersion-based cognitive intra-individual variability in former American football players: Association with traumatic encephalopathy syndrome, repetitive head impacts, and biomarkers.
Clin Neuropsychol
January 2025
Department of Neurology, Boston University Alzheimer's Disease Research Center, Boston University CTE Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Exposure to repetitive head impacts (RHI), such as those experienced in American football, is linked to cognitive dysfunction later in life. Traumatic encephalopathy syndrome (TES) is a proposed clinical syndrome thought to be linked to neuropath-ology of chronic traumatic encephalopathy (CTE), a condition associated with RHI from football. Cognitive intra-individual variability (d-CIIV) measures test-score dispersion, indicating cognitive dysfunction.
View Article and Find Full Text PDFPrediction of atrial fibrillation after a stroke event: a systematic review with meta-analysis.
Heart Rhythm
January 2025
Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK; Leeds Institute of Data Analytics, University of Leeds, Leeds, UK; Department of Cardiology, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Background: Detecting atrial fibrillation (AF) after stroke is a key component of secondary prevention, but indiscriminate prolonged cardiac monitoring is costly and burdensome. Multivariable prediction models could be used to inform patient selection.
Objective: To determine the performance of available models for predicting AF after a stroke.
Author's Reply to Impact of Mavacamten on Atrial Fibrillation in Patients with Obstructive Hypertrophic Cardiomyopathy.
Heart Rhythm
January 2025
Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA; Department of Molecular Pharmacology & Experimental Therapeutics (Windland Smith Rice Sudden Death Genomics Laboratory). Electronic address:
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