AI Article Synopsis
- Primary sclerosing cholangitis (PSC) is a chronic liver condition linked to inflammatory bowel disease, causing damage to bile ducts and increasing risks of liver failure and cancer.
- The complexity and variability of PSC, combined with its rarity, have made it challenging to develop effective treatments.
- Recent advancements in understanding PSC's diagnosis and potential therapies offer hope for better management and outcomes in the future.
Article Abstract
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by fibroinflammatory damage to the biliary tree, typically in the setting of inflammatory bowel disease, with an increased risk of liver failure and cholangiocarcinoma. A complex pathophysiology, heterogeneity in clinical features, and the rare nature of the disease have contributed to the lack of effective therapy to date. However, recent innovations in the characterization and prognostication of patients with PSC, in addition to new tools for medical management and emerging pharmacologic agents, give rise to the potential for meaningful progress in the next several years. This review summarizes current concepts in PSC and highlights particular areas in need of further study.
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| http://dx.doi.org/10.1016/j.cgh.2023.04.004 | DOI Listing |
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