Problems with the definition of type II second degree AV block are best understood by reviewing the historical aspects that include Mobitz's original description, the contributions of the Chicago Arrhythmia School and the growing importance of excluding slowing of the sinus rhythm.
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| http://dx.doi.org/10.1016/j.jelectrocard.2023.03.086 | DOI Listing |
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Evaluating cognitive bias in clinical ethics supports: a scoping review.
BMC Med Ethics
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Unité de Neurophysiologie du Stress, Institut de Recherche Biomédicale Des Armées, Brétigny Sur Orge Cedex, 91223, France.
Background: A variety of cognitive biases are known to compromise ethical deliberation and decision-making processes. However, little is known about their role in clinical ethics supports (CES).
Methods: We searched five electronic databases (Pubmed, PsychINFO, the Web of Science, CINAHL, and Medline) to identify articles describing cognitive bias in the context of committees that deliberate on ethical issues concerning patients, at all levels of care.
Curcumin administration alleviates seminal vesicle damage in type 1 diabetic rats by promoting AQP8 expression through AR activation.
Sci Rep
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Department of andrology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, China.
Diabetes is a detriment to male reproductive health, notably through its capacity to diminish secretion from accessory glands such as the seminal vesicles and prostate, which are crucial for reproductive function. Curcumin, a naturally derived polyphenol renowned for its anti-inflammatory and antioxidative attributes, has demonstrated potential in mitigating tissue damage across various organs in diabetic patients. Despite its established benefits, the specific impact of curcumin on seminal vesicle damage in the context of diabetes remains underexplored.
View Article and Find Full Text PDFMetaQ: fast, scalable and accurate metacell inference via single-cell quantization.
Nat Commun
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School of Computer Science, Sichuan University, Chengdu, Sichuan, China.
To overcome the computational barriers of analyzing large-scale single-cell sequencing data, we introduce MetaQ, a metacell algorithm that scales to arbitrarily large datasets with linear runtime and constant memory usage. Inspired by cellular development, MetaQ conceptualizes each metacell as a collective ancestor of biologically similar cells. By quantizing cells into a discrete codebook, where each entry represents a metacell capable of reconstructing the original cells it quantizes, MetaQ identifies homogeneous cell subsets for efficient and accurate metacell inference.
View Article and Find Full Text PDFImpact of epidural analgesia on outcomes of vaginal birth after cesarean delivery.
Arch Gynecol Obstet
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Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Primary Objective: To assess the association between Epidural Analgesia (EA) during Vaginal Birth After Cesarean (VBAC) and delivery mode (spontaneous or instrumental vaginal delivery). Secondary objectives include maternal and neonatal outcomes.
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Proteoglycan-degrading enzymes engineered for enhanced tumor microenvironment interaction in renal cell carcinoma.
Int J Biol Macromol
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Second Department of Cardiovascular Medicine, Shengjing Hospital Affiliated to China Medical University, No. 36, Sanhao Street, Heping District, Shenyang 110004, Liaoning Province, China. Electronic address:
This work optimized proteoglycan-degrading enzymes through targeted mutagenesis to enhance their interaction with the tumor microenvironment in Renal Cell Carcinoma (RCC). A comprehensive mutagenesis approach identified 60 key mutations significantly improving enzymatic activity, stability, and structural integrity. When compared to Wild Type (WT) enzyme, a remarkable increase in specific activity by 35 % (p < 0.
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