We use projected entangled-pair states (PEPS) to calculate the large deviation statistics of the dynamical activity of the two-dimensional East model, and the two-dimensional symmetric simple exclusion process (SSEP) with open boundaries, in lattices of up to 40×40 sites. We show that at long times both models have phase transitions between active and inactive dynamical phases. For the 2D East model we find that this trajectory transition is of the first order, while for the SSEP we find indications of a second order transition. We then show how the PEPS can be used to implement a trajectory sampling scheme capable of directly accessing rare trajectories. We also discuss how the methods described here can be extended to study rare events at finite times.
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http://dx.doi.org/10.1103/PhysRevLett.130.147401 | DOI Listing |
JACS Au
January 2025
Key Lab for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.
The creation of spatially coupled meso-/microenvironments with biomimetic compartmentalized functionalities is of great significance to achieve efficient signal transduction and amplification. Herein, using a soft-template strategy, UiO-67-type hierarchically mesoporous metal-organic frameworks (HMMOFs) were constructed to satisfy the requirements of such an artificial system. The key to the successful synthesis of HMUiO-67 is rooted in the utilization of the preformed cerium-oxo clusters as metal precursors, aligning the growth of MOF crystals with the mild conditions required for the self-assembly of the soft template.
View Article and Find Full Text PDFChem Sci
January 2025
School of Physical Science and Technology, ShanghaiTech University Shanghai 201210 China
The process of proton translocation in , triggered by light, is powered by the photoisomerization of all--retinal in bacteriorhodopsin (bR). The primary events in bR involving rapid structural changes upon light absorption occur within subpicoseconds to picoseconds. While the three-state model has received extensive support in describing the primary events between the H and K states, precise characterization of each excited state in the three-state model during photoisomerization remains elusive.
View Article and Find Full Text PDFFront Public Health
January 2025
School of Languages and Media, Anhui University of Finance and Economics, Bengbu, China.
Background: The social problems caused by depressive disorders and psychological behaviors in women are increasingly prominent, with extreme incidents occurring from time to time. Therefore, the issue concerning "how to prevent and resolve the risk of depression in women" is gaining significant attention across various sectors. However, previous studies have largely focused on teenage girls, perimenopausal women, or women during pregnancy and the postpartum period, neglecting the adverse effects of major diseases, which is detrimental to enhancing the psychological well-being of women with cancer.
View Article and Find Full Text PDFJACC Asia
January 2025
Department of Cardiovascular Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Background: Pericoronary adipose tissue attenuation (PCATA) is a novel imaging biomarker of pericoronary inflammation associated with coronary artery disease. Several studies have reported the usefulness of PCATA among people of European ethnicity; however, data are lacking concerning those of Asian ethnicity.
Objectives: This multicenter study aimed to evaluate the effect of PCATA on prognosis in East Asian patients.
Objective: Fluoropyrimidine chemotherapy is a first-line treatment for many gastrointestinal (GI) cancers, however, cardiotoxicity concerns may limit administration in patients with pre-existing cardiovascular disease (CVD). This study investigated the association of pre-existing CVD with use of fluoropyrimidine chemotherapy in tumour-eligible GI cancer patients.
Methods And Analysis: National cancer registry data from the Virtual Cardio-Oncology Research Initiative from England between 2014 and 2018 was used to identify GI cancer patients eligible to receive fluoropyrimidine chemotherapy.
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