Objectives: Pectoserratus plane block (PSPB) leads to lower postoperative pain intensity. We examined whether PSPB could also reduce the incidence of post-mastectomy pain syndrome (PMPS) in women undergoing breast cancer surgery.
Methods: We performed an extension study of a randomized trial that compared PSPB versus control in women undergoing mastectomy. The primary outcome was any chronic pain at the surgical site or adjacent areas, defined as persistent/recurrent pain lasting ≥3 months. Secondary outcomes included neuropathic pain (score ≥4 in the Douleur Neuropathique 4 questionnaire), use of analgesic/anti-inflammatory drugs, pain intensity through the short-form McGill Pain Questionnaire, and type, frequency, and location of the pain.
Results: Of the 60 patients that completed the 24-hour follow-up (short-term trial), 53 (88%) completed the long-term follow-up (27 in the PSPB group and 26 in the placebo group). Six of 27 patients (22%) in the PSPB group and 17 of 26 patients (65%) in the placebo group reported any chronic pain (relative risk [RR], 0.34; 95% confidence interval [95% CI]=0.16-0.73, P =0.005). The risk of neuropathic pain was also lower in the PSPB group than in the placebo group (18.5% vs. 54%, respectively; RR, 0.34; 95% CI=0.14-0.82, P =0.02). There were no differences regarding all other pain-related outcomes considering the patients who developed PMPS.
Discussion: The results suggest that, in the long term, PSPB-treated participants were associated with a statistically significantly lower risk of PMPS than those who received standard general anesthesia.
Trial Registration: ClinicalTrials.gov (NCT03966326).
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/AJP.0000000000001118 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The size of the happy face advantage-faster categorization of happy faces-is modulated by interactions between perceiver and target social categories, with reliable happy face advantages for ingroups but not necessarily outgroups. The current understanding of this phenomenon is constrained by the limited social categories typically used in experiments. To better understand the mechanism(s) underpinning social category modulation of the happy face advantage, we used racially more diverse samples of perceivers and target faces and manipulated the intergroup context in which they appeared.
View Article and Find Full Text PDFEffects of meloxicam and flunixin meglumine on oxidative stress and pregnancy factors in Awassi sheep.
Vet Rec
January 2025
Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, Harran University, Sanliurfa, Turkey.
Background: This study aimed to evaluate the effects of administering flunixin meglumine (FM) and meloxicam (M) on specific days post-mating on progesterone (P4), total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), pregnancy-specific protein B (PSPB), pregnancy-associated glycoprotein (PAG) concentrations and fertility parameters in Awassi sheep.
Methods: Seventy-five Awassi sheep were divided into three groups of 25: control, M and FM. On days 9 and 10 post-mating, the control group received saline, the M group received 0.
On the Limits of Anonymization for Promoting Diversity in Organizations.
Pers Soc Psychol Bull
January 2025
Negotiation, Organizations & Markets Unit, Harvard Business School, Harvard University, Boston, Massachusetts.
Anonymization of job applicant resumes is a recommended strategy to increase diversity in organizations, but large-scale tests have shown mixed results. We consider decision-makers' social dominance orientation (SDO), a measure of anti-egalitarianism/endorsement of group-based hierarchy, to illustrate the limits of anonymization. Across four pre-registered studies ( = 3,150), we show that (a) lower SDO individuals are less likely to hire individuals from underrepresented groups when job materials are anonymized and (b) they are more likely to opt into using anonymization.
View Article and Find Full Text PDFThe Aversive Racism Theory of Cultural Appropriation: Attributions of Target Intent Suppresses Evaluations of Intergroup Harm.
Pers Soc Psychol Bull
December 2024
University of California, Davis, USA.
This research investigates whether racially dominant (White) and minoritized group members (Black) differentially evaluate intergroup harm in ambiguous (vs. overt) acts of cultural appropriation (the aversive racism hypothesis), due to attributions of positive intentions to the target (the intent as justification hypothesis). Four experiments ( = 1,020, 3 preregistered) and an internal meta-analysis converge to demonstrate that White perceivers evaluated less harm than Black perceivers in ambiguous acts of cultural appropriation.
View Article and Find Full Text PDFStereotype Threat at Work: A Meta-Analysis.
Pers Soc Psychol Bull
December 2024
Leipzig University, Germany.
Stereotype threat refers to the concern of being judged based on stereotypes about one's social group. This preregistered meta-analysis examines the correlates of stereotype threat in the workplace ( = 61 independent samples, 40,134). Results showed that stereotype threat was positively related to exhaustion, identity separation, negative affect, turnover intentions, and behavioral coping, and negatively related to career aspirations, job satisfaction, organizational commitment, job engagement, job performance, positive affect, self-efficacy, and work authenticity.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!