AI Article Synopsis
- Therapeutic antibodies are crucial in fighting coronavirus, but many developed early in the pandemic are ineffective against newer strains, especially Omicron.
- Researchers have identified a group of antibodies from vaccinated individuals that show effective neutralization across multiple virus variants.
- The study suggests these antibodies have unique structural properties and effectiveness in protecting against specific Omicron infections in a mouse model, paving the way for future broad-spectrum antibody therapies.
Article Abstract
Therapeutic antibodies are an important tool in the arsenal against coronavirus infection. However, most antibodies developed early in the pandemic have lost most or all efficacy against newly emergent strains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), particularly those of the Omicron lineage. Here, we report the identification of a panel of vaccinee-derived antibodies that have broad-spectrum neutralization activity. Structural and biochemical characterization of the three broadest-spectrum antibodies reveal complementary footprints and differing requirements for avidity to overcome variant-associated mutations in their binding footprints. In the K18 mouse model of infection, these three antibodies exhibit protective efficacy against BA.1 and BA.2 infection. This study highlights the resilience and vulnerabilities of SARS-CoV-2 antibodies and provides road maps for further development of broad-spectrum therapeutics.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083196 | PMC |
| http://dx.doi.org/10.1016/j.celrep.2023.112421 | DOI Listing |
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