The lack of real-time monitoring is one of the reasons for the lack of awareness among drivers of their dangerous driving behavior. This work aims to develop a driver profiling system where a smartphone's built-in sensors are used alongside machine learning algorithms to classify different driving behaviors. We attempt to determine the optimal combination of smartphone sensors such as accelerometer, gyroscope, and GPS in order to develop an accurate machine learning algorithm capable of identifying different driving events (e.g. turning, accelerating, or braking). In our preliminary studies, we encountered some difficulties in obtaining consistent driving events, which had the potential to add "noise" to the observations, thus reducing the accuracy of the classification. However, after some pre-processing, which included manual elimination of extraneous and erroneous events, and with the use of the Convolutional Neural Networks (CNN), we have been able to distinguish different driving events with an accuracy of about 95%. Based on the results of preliminary studies, we have determined that the proposed approach is effective in classifying different driving events, which in turn will allow us to determine driver's driving behavior.
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http://dx.doi.org/10.12688/f1000research.73134.2 | DOI Listing |
Alzheimers Dement
December 2024
Icahn School Of Medicine at Mount Sinai, New York, NY, USA.
Background: Despite increasing knowledge of the etiology of neurodegenerative diseases, translation of these benefits into therapeutic advances for Alzheimer's Disease and related diseases (ADRD) has been slow. Drug repurposing is a promising strategy for identifying new uses for approved drugs beyond their initial indications. We developed a high-throughput drug screening platform aimed at identifying drugs capable of reducing proteotoxicity in vivo (Aß toxicity in Caenorhabditis elegans) AND inhibiting microglial inflammation (TNF-alpha IL-6), both implicated in driving AD(figure attached with sample of results in C.
View Article and Find Full Text PDFDis Aquat Organ
January 2025
Mississippi Aquarium, Department of Veterinary Services, Gulfport, Mississippi 39502, USA.
This report documents complications in false pilchard Harengula clupeola and scad Decapterus macarellus associated with a salinomycin (60 mg kg-1) and amprolium (100 mg kg-1) gel feed treatment, along with prolonged temperature increase, for an Enteromyxum leei outbreak in a salt water, mixed species, public aquarium exhibit. Shortly after administration, a mass mortality event ensued where hundreds of false pilchards and a few scad died. Medicated gel feed was noted within the gastrointestinal tracts of all affected fish.
View Article and Find Full Text PDFInt J Biol Sci
January 2025
The People's Hospital of Gaozhou, Gaozhou 525200, China.
Cyclin D3 (CCND3), a member of the cyclin D family, is known to promote cell cycle transition. In this study, we found that CCND3 was downregulated in cisplatin-resistant (-diamminedichloroplatinum, DDP) lung adenocarcinoma (LUAD) cells. The loss of CCND3 indeed impeded cell cycle transition.
View Article and Find Full Text PDFNature
January 2025
Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.
Oncogenic mutations that drive colorectal cancer can be present in healthy intestines for long periods without overt consequence. Mutation of Adenomatous polyposis coli (Apc), the most common initiating event in conventional adenomas, activates Wnt signalling, hence conferring fitness on mutant intestinal stem cells (ISCs). Apc mutations may occur in ISCs that arose by routine self-renewal or by dedifferentiation of their progeny.
View Article and Find Full Text PDFBrain Stimul
January 2025
MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.
Background: Selective attention is a fundamental cognitive mechanism that allows people to prioritise task-relevant information while ignoring irrelevant information. Previous research has suggested key roles of parietal event-related potentials (ERPs) and alpha oscillatory responses in attention tasks. However, the informational content of these signals is less clear, and their causal effects on the coding of multiple task elements are yet unresolved.
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