In order to determine if blood gases and haemodynamic variables were steady after right heart catheterization, measurements were performed as soon as the catheter was placed, and after an interval ranging between 15 and 25 min in 22 patients with chronic lung disease. This study shows that there was no significant difference in blood gases, systemic and pulmonary vascular pressures, or cardiac output, except for pulmonary wedge pressure which decreased by 1.1 mmHg on average, and PaO2 which increased by 2.8 mmHg on average; these changes were indeed of small magnitude. Individual changes were usually small, but occasionally changes in vascular pressures of several mmHg could be observed. The stability of blood gases and haemodynamic variables can be explained by the lack of anxiety in these patients who had been familiarized with the equipment and the procedure the day before the examination, and also by the relaxed atmosphere during the procedure, which prevents apprehension with its haemodynamic consequences.
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Sensors (Basel)
January 2025
Research Centre for Biomedical Engineering, City St George's, University of London, London, EC1V 0HB, UK.
Over the past ten years, there has been an increasing demand for reliable consumer wearables as users are inclined to monitor their health and fitness metrics in real-time, especially since the COVID-19 pandemic. Reflectance pulse oximeters in fitness trackers and smartwatches provide convenient, non-invasive SpO measurements but face challenges in achieving medical-grade accuracy, particularly due to difficulties in capturing physiological signals, which may be affected by skin pigmentation. Hence, this study sets out to investigate the influence of skin pigmentation, particularly in individuals with darker skin, on the accuracy and reliability of SpO measurement in consumer wearables that utilise reflectance pulse oximeters.
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January 2025
Research Centre for Biomedical Engineering, City St George's, University of London, London EC1V 0HB, UK.
The effect of skin pigmentation on photoplethysmography and, specifically, pulse oximetry has recently received a significant amount of attention amongst researchers, especially since the COVID-19 pandemic. With most computational studies observing overestimation of arterial oxygen saturation (SpO) in individuals with darker skin, this study seeks to further investigate the root causes of these discrepancies. This study analysed intensity changes from Monte Carlo-simulated reflectance PPG signals across light, moderate, and dark skin types at oxygen saturations of 70% and 100% in MATLAB R2024a.
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January 2025
Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, 168 Litang Road, Changping District, Beijing 102218, China.
(1) Background: To develop a novel capillary refill time measurement system and evaluate its reliability and reproducibility. (2) Methods: Firstly, the utilization of electromagnetic pressure technology facilitates the automatic compression and instantaneous release of the finger. Secondly, the employment of pressure sensing technology and photoelectric volumetric pulse wave analysis technology enables the dynamic monitoring of blood flow in distal tissues.
View Article and Find Full Text PDFJ Clin Med
January 2025
Newborn Research, Department of Neonatology, University Hospital Zurich, CH-8091 Zurich, Switzerland.
: Hypoxic-ischemic encephalopathy (HIE) in late preterm and term neonates accounts for neonatal mortality and unfavorable neurodevelopmental outcomes in survivors despite therapeutic hypothermia (TH) for neuroprotection. The circumstances of death in neonates with HIE, including involvement of neonatal palliative care (NPC) specialists and neurodevelopmental follow-up at 18-24 months in survivors, warrant further evaluation. : A retrospective multicenter cohort study including neonates ≥ 35 weeks gestational age with moderate to severe HIE receiving TH, registered in the Swiss National Asphyxia and Cooling Register between 2011 and 2021.
View Article and Find Full Text PDFInt J Mol Sci
January 2025
Laboratory of Foodomics, Institute of Food Science Research, CIAL, CSIC, Nicolás Cabrera 9, 28049 Madrid, Spain.
This study investigates the biorefinery approach to extracting blood-brain barrier (BBB)-permeable compounds from Labill. and L. for neuroprotective purposes.
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