AI Article Synopsis
- - A study examined archived tissue samples from three lions that had nonsuppurative meningoencephalitis and vasculitis, leading to the discovery of rustrela virus (RusV).
- - Researchers used techniques like reverse transcription quantitative PCR, immunohistochemistry, and in situ hybridization to confirm the presence of RusV in different types of brain cells, including cortical neurons and astrocytes.
- - The findings indicate that RusV is associated with neurological issues in lions, highlighting the virus's impact on brain health in these animals.
Article Abstract
Retrospective investigation of archived tissue samples from 3 lions displaying nonsuppurative meningoencephalitis and vasculitis led to the detection of rustrela virus (RusV). We confirmed RusV antigen and RNA in cortical neurons, axons, astrocytes and Purkinje cells by reverse transcription quantitative PCR, immunohistochemistry, and in situ hybridization.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10124629 | PMC |
| http://dx.doi.org/10.3201/eid2905.230172 | DOI Listing |
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