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Safety and Antioxidant Assessments of BLR-E50, 50% Ethanolic Extract from Red Beans Co-fermented by Bacillus subtilis and Lactobacillus bulgaricus.
Food Chem Toxicol
January 2025
Department of Pathology, School of Medicine, Chung Shan Medical University, Taichung, 40201, Taiwan; Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, 40201, Taiwan. Electronic address:
Since red beans have poor textural properties, fermentation is commonly used to help produce better pulse products. To obtain BLR-E50, red beans are fermented using a co-culture of Bacillus subtilis and Lactobacillus bulgaricus, followed by extraction with 50% ethanol. The present data demonstrate that BLR-E50 did not exhibit mutagenicity, genotoxicity, or subacute oral toxicity.
View Article and Find Full Text PDFTargeted apoptosis in breast cancer cells via niosome-mediated delivery of cyclophosphamide and sodium oxamate.
Mol Biol Rep
January 2025
Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
Objective: Breast cancer is the most frequently diagnosed cancer among women, posing significant health risks. This study investigates niosome nanoparticles as a delivery system for Cyclophosphamide (CYC) and Sodium Oxamate (SO) to target apoptotic pathways in MDA-MB-231 breast cancer cells.
Methods: Lipid-based niosomes were prepared using the thin-film hydration method and characterized for size, zeta potential, and Fourier-transform infrared spectroscopy (FTIR) profiles.
Internet of Things (IoT)-Driven Fermentation System for Enhanced Cordycepin Production in Cordyceps militaris (Ascomycetes) under Hypoxic Conditions.
Int J Med Mushrooms
January 2025
Department of Food Science and Technology, Central Taiwan University of Science and Technology, Taichung City 406053, Taiwan (R.O.C.).
Cordycepin, known for its tumor-suppressive and antiviral properties, has garnered attention due to its therapeutic and biological potential. Current Cordyceps militaris - based cordycepin production methods involve time-consuming and cost-intensive solid-state fermentation. Using an internet of things (IoT) architecture, we developed an active air-feed regulation fermentation system (AAFRFS) to detect CO2 emitted during C.
View Article and Find Full Text PDFA perspective review on factors that influence mutagenicity in medicinal plants and their health implications.
Toxicol Sci
January 2025
Department of Pharmacology, University of the Free State, Bloemfontein, 9300, South Africa.
Medicinal plants are products from natural sources that have found relevance in medicine for several decades. They are rich in bioactive compounds; thus, they are widely used to treat different ailments globally. Medicinal plants have provided hope for the health care industry as most are used to synthesize modern medicines currently used in the treatment of various diseases.
View Article and Find Full Text PDFInvestigating the Immunogenic Properties of a Mutagenized NS3/4A-Based HCV Genotype 3a DNA Vaccine.
Viral Immunol
January 2025
Faculty of Allied Health Sciences, Burapha University, Muang, Thailand.
Chronic hepatitis C virus (HCV) infection poses a major health risk worldwide, with patients susceptible to liver cirrhosis and hepatocellular carcinoma. This study focuses on the development of effective therapeutic strategies for HCV infection through the investigation of immunogenic properties of a DNA construct based on the NS3/4A gene of HCV genotype (g)3a. Gene expression of the mutagenized (mut) NS3/4A target genes was assessed through reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and Western blot analysis.
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