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Target protein identification in live cells and organisms with a non-diffusive proximity tagging system.
Elife
December 2024
Department of Neurology, Medical Research Institute, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.
Identifying target proteins for bioactive molecules is essential for understanding their mechanisms, developing improved derivatives, and minimizing off-target effects. Despite advances in target identification (target-ID) technologies, significant challenges remain, impeding drug development. Most target-ID methods use cell lysates, but maintaining an intact cellular context is vital for capturing specific drug-protein interactions, such as those with transient protein complexes and membrane-associated proteins.
View Article and Find Full Text PDFEffects of Nanosilica on the Properties of Ultrafine Cement-Fly Ash Composite Cement Materials.
Nanomaterials (Basel)
December 2024
School of Civil Engineering and Architecture, Henan University, Kaifeng 475000, China.
The increasing incidence of structural failures, such as cracks and collapses, in rock masses within mines, tunnels, and other civil engineering environments has attracted considerable attention among scholars in recent years. Grouting serves as a principal solution to these issues. The Renlou Coal Mine in the Anhui Province is used as a case study to evaluate the effectiveness of nanosilica (NS) as an additive in ultrafine cement (UC), introducing a novel grouting material for practical applications.
View Article and Find Full Text PDFPreparation and Characterization of Ultrasonically Modified Peanut Protein-Guar Gum Composite Emulsion Gels for 3D Printing.
Gels
December 2024
College of Food Science and Engineering, Henan University of Technology, Zhengzhou 450001, China.
This study aimed to prepare ultrasonically modified peanut protein-guar gum composite emulsion gels for 3D printing. The composition of the composite emulsion gels was determined in single-factor and orthogonal experiments. The results revealed that the optimal composite emulsion gels consisted of 6% peanut protein, 50% oil and 0.
View Article and Find Full Text PDFA signal processing tool adapted to the periodic biphasic phenomena: the Dynalet transform.
Math Med Biol
December 2024
Escuela de Ingeniería Civil Informática, Universidad de Valparaíso, General Cruz 222, Valparaíso, Chile.
The linear functional analysis, historically founded by Fourier and Legendre (Fourier's supervisor), has provided an original vision of the mathematical transformations between functional vector spaces. Fourier, and later Laplace and Wavelet transforms, respectively defined using the simple and damped pendulum, have been successfully applied in numerous applications in Physics and engineering problems. However the classical pendulum basis may not be the most appropriate in several problems, such as biological ones, where the modelling approach is not linked to the pendulum.
View Article and Find Full Text PDFLearning enhances behaviorally relevant representations in apical dendrites.
Elife
December 2024
Department of Neuroscience, Columbia University, New York, United States.
Learning alters cortical representations and improves perception. Apical tuft dendrites in cortical layer 1, which are unique in their connectivity and biophysical properties, may be a key site of learning-induced plasticity. We used both two-photon and SCAPE microscopy to longitudinally track tuft-wide calcium spikes in apical dendrites of layer 5 pyramidal neurons in barrel cortex as mice learned a tactile behavior.
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