AI Article Synopsis
- Dengue, often seen as an urban issue, poses significant risks to rural communities, prompting a study in northwestern Ecuador to investigate its transmission dynamics.
- A phylogenetic analysis revealed the presence of DENV-1 and DENV-2 in samples collected from febrile patients between 2019 and 2021, indicating the active circulation of these virus strains.
- Findings suggest that while larger communities with commercial centers are primary sources of DENV, smaller, more remote areas also contribute to the overall transmission in the region.
Article Abstract
Although dengue is typically considered an urban disease, rural communities are also at high risk. To clarify dynamics of dengue virus (DENV) transmission in settings with characteristics generally considered rural (e.g., lower population density, remoteness), we conducted a phylogenetic analysis in 6 communities in northwestern Ecuador. DENV RNA was detected by PCR in 121/488 serum samples collected from febrile case-patients during 2019-2021. Phylogenetic analysis of 27 samples from Ecuador and other countries in South America confirmed that DENV-1 circulated during May 2019-March 2020 and DENV-2 circulated during December 2020-July 2021. Combining locality and isolation dates, we found strong evidence that DENV entered Ecuador through the northern province of Esmeraldas. Phylogenetic patterns suggest that, within this province, communities with larger populations and commercial centers were more often the source of DENV but that smaller, remote communities also play a role in regional transmission dynamics.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10124659 | PMC |
| http://dx.doi.org/10.3201/eid2905.221226 | DOI Listing |
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