AI Article Synopsis
- Cutaneous leishmaniasis and visceral leishmaniasis, caused by various Leishmania species, have been reported in Israel, prompting a study of sand flies in the Negev desert.
- Researchers trapped over 22,000 sand flies, predominantly P. alexandri, and found that 2.5% of female flies tested positive for Leishmania DNA, with 92% of those infections being L. donovani.
- The study indicates that L. donovani is circulating in the region and highlights the importance of rapid diagnosis and species identification to combat leishmaniasis effectively.
Article Abstract
Cutaneous leishmaniasis caused by Leishmania major or L. tropica and visceral leishmaniasis caused by L. infantum have been reported in Israel. We collected Phlebotomus spp. sand flies in the Negev desert of southern Israel to identify circulating Leishmania spp. Of 22,636 trapped sand flies, 80% were P. alexandri. We sequenced Leishmania-specific internal transcribed spacer 1 fragments and K26 genes. Of 5,019 Phlebotomus female sand flies, 2.5% were Leishmania DNA-positive; 92% of infections were L. donovani. Phylogenetic analyses showed separate clustering of L. donovani and L. infantum. P. alexandri flies positive for L. donovani harbored blood meals from European hares. Leishmania DNA isolated from a patient with cutaneous leishmaniasis who lived in the survey area was identical to L. donovani from P. alexandri flies. We report circulation of L. donovani, a cause of visceral leishmaniasis, in southern Israel. Prompt diagnosis and Leishmania spp. identification are critical to prevent leishmaniasis progression.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10124660 | PMC |
| http://dx.doi.org/10.3201/eid2905.221657 | DOI Listing |
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