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Combined therapy with pirfenidone and nintedanib counteracts fibrotic silicosis in mice.
Br J Pharmacol
November 2024
State Key Laboratory of Respiratory Health and Multimorbidity, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China.
Background And Purpose: Pneumoconiosis, especially silicosis, is a prevalent occupational disease with substantial global economic implications and lacks a definitive cure. Both pneumoconiosis and idiopathic pulmonary fibrosis (IPF) are interstitial lung diseases, which share many common physiological characteristics. Because pirfenidone and nintedanib are approved to treat IPF, their potential efficacy as antifibrotic agents in advanced silicosis deserves further exploration.
View Article and Find Full Text PDFEtiological, sociodemographic and clinical characteristics of sexually transmitted infections and resistance in Shenzhen: a multicenter cross-sectional study in China.
Front Cell Infect Microbiol
August 2024
NHC Key Laboratory of Systems Biology of Pathogens, National Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Article Synopsis
- The study investigates the characteristics and resistance levels of sexually transmitted infections (STIs) in Shenzhen, China, with a focus on sociodemographic factors.
- A total of 7,886 sexually active participants were screened for various STI-related organisms, revealing that being single, divorced, or having lower education increases the risk of STI detection.
- High levels of antimicrobial resistance were found, with a significant percentage of samples showing mutations linked to treatment resistance, indicating a need for more awareness and action regarding STI prevention and treatment in specific high-risk groups.
[Polypharmacy and medication review in the context of prehabilitation].
Urologie
October 2023
Curos urologisches Zentrum, Köln, Abteilung für Urologie, Klinik Links vom Rhein, Köln, Deutschland.
Against the background of typical geriatric multimorbidity and with the particular vulnerability of geriatric patients, polypharmacy deserves special attention. In accordance with the guidelines, medication should not only be reviewed regularly, but also on an ad hoc basis and with each hospital stay-and also in the context of prehabilitation. Thus, not only substances that interfere with the currently planned intervention, anesthesia, or risk of bleeding should be considered, but any medication that increases common risks for geriatric patients.
View Article and Find Full Text PDFGeneralized anxiety disorder (GAD) and major depressive disorder (MDD) frequently occur together, but sociodemographic, behavioral, and diagnostic correlates of this comorbidity have not been comprehensively studied. Data from the nationally representative US sample surveyed in the National Epidemiologic Survey on Alcohol and Related Conditions-III ( N = 36,309) were used to define three groups, individuals with a) both past-year GAD and MDD ( n = 909, 16.9%), b) GAD only ( n = 999, 18.
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