AI Article Synopsis
- Peroxynitrite (ONOO) is common in living organisms and plays a role in various health issues, making it important to create effective detection tools for it.* -
- A new fluorescent probe called B-Ch was developed using a technique called intramolecular charge transfer (ICT), which enhances its ability to detect ONOO effectively by changing a chemical group.* -
- This probe displays clear color and fluorescence changes upon reacting with ONOO, highlighting its advantages, such as visual detection, high selectivity, low sensitivity threshold (22.4 nM), and suitability for cellular imaging.*
Article Abstract
Peroxynitrite is widely present in organisms and closely related to many pathophysiological functions. Therefore, it is of great physiological significance to develop capable probes for detecting ONOO. In this work, a novel fluorescent probe B-Ch was designed based on the intramolecular charge transfer (ICT) effect. By means of molecular engineering, the replacement from diethylamine group to hydroxyl group has improved the detection sensitivity of the probe. After the addition of ONOO, the solution color and fluorescence showed noticeable changes, which were visible to the naked eye. The probe showed excellent advantages: visualization, good selectivity, low sensitivity (22.4 nM), good stability and biocompatibility, exogenous and endogenous imaging of ONOO in HeLa cells.
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| http://dx.doi.org/10.1016/j.saa.2023.122747 | DOI Listing |
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