Reversible pH-responsive -methoxyoxazolidine formation is used to ligate split aptamer fragments. Two twice-split models and one thrice-split model of CBA (cocaine-binding aptamer) were examined. The aptamer assembly was dynamic, proportional to the substrate concentration and occurred without interfering background ligation.
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| http://dx.doi.org/10.1039/d3cc01158e | DOI Listing |
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