AI Article Synopsis
- The study aimed to find non-invasive methods for diagnosing alcoholic steatohepatitis (ASH) instead of relying on costly and invasive liver biopsies.
- Researchers measured the serum levels of K18-M65 in patients with alcohol withdrawal and found that it had good diagnostic accuracy, helping to classify a significant percentage of cases.
- A new combined scoring system that includes K18-M65 and other clinical factors showed even higher accuracy for diagnosing ASH, potentially aiding in treatment decisions and prompting patients to reduce alcohol intake.
Article Abstract
Background And Aims: The diagnosis of alcoholic steatohepatitis (ASH) is based on liver biopsy, which is costly and invasive with non-negligible morbidity. The aim of this study was to evaluate the accuracy of circulating cytokeratin 18 M65 fragment (K18-M65) alone or in association with other markers for the non-invasive diagnosis of ASH in patients ongoing alcohol withdrawal.
Methods: This study examined the serum level of K18-M65 in a test cohort of 196 patients. All patients underwent liver biopsy, transient elastography (TE) and serum collection. The diagnostic accuracy of K18-M65 alone or combined with clinico-biological data was assessed and the best defined cut-offs were validated in an independent validation cohort of 58 patients.
Results: K18-M65 had an area under the curve (AUC) of 0.82 (test cohort) and 0.90 (validation cohort). Using two cut-off decision points, K18-M65 was able to classify 46.9% (test cohort) and 34.5% (validation cohort) of patients with 95% sensitivity or specificity. Combining K18-M65, alpha-2-macroglobulin, TE, body mass index, and age, we created a score allowing accurate diagnosis of ASH with an AUC of 0.93 (test cohort) and 0.94 (validation cohort). This new score was able to rule out or rule in the diagnosis of steatohepatitis for probability ≤0.135 or ≥0.667 respectively in more than two-thirds of patients.
Conclusions: We propose a new validated non-invasive score for the diagnosis of ASH in patients ongoing alcohol withdrawal. This score can help to identify patients that may benefit from potential therapeutics or motivate them to reduce alcohol consumption.
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| http://dx.doi.org/10.1111/apt.17515 | DOI Listing |
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