Background: Due to the surge in high-speed road traffic accidents during the past few years, extra-articular proximal tibia fractures have also risen in number. For the treatment of such fractures, various options are available like conservative treatment with casting, surgical treatment with plate osteosynthesis, or a hybrid external fixator. Exposure of the bone surface and extensive soft tissue dissection is needed in bridge plating, posing a risk of bleeding, infection, and soft-tissue healing issues, and the blood supply of the fractured area is also hampered as the periosteum is also destroyed. To avoid these complications, a hybrid external fixator can be used but it has its own risks of malunion, non-union, and pin-tract infections; another drawback is patient compliance. In this study, we compare the clinical and functional outcomes of two treatment modalities, i.e., bridge plating and hybrid external fixator, in the treatment of proximal tibia metaphyseal fractures.
Materials And Methods: This prospective randomized study was conducted from February 2021 to June 2022 on 46 adult patients diagnosed with proximal tibia metaphyseal fracture and willing to participate. An odd number of patients were treated with a bridge plate and even with a hybrid external fixator.
Results: A total of 46 patients were included in the study, sustaining proximal tibia metaphyseal fracture, out of which 23 patients underwent hybrid external fixation with an outcome of 69.43 ± 8.11 according to the Knee Society Score (KSS) and 23 for bridge plating which showed better results as their score at final follow-up was 75.00 ± 8.22.
Conclusion: According to our study, we found that bridge plating is a better treatment modality than the hybrid external fixator as the former showed better postoperative knee range of motion and functional outcome and led to a smaller number of complications. But the clinical outcome would also be influenced by the type of fracture, degree of comminution, type of injury, i.e., open or closed, and quality of bone.
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http://dx.doi.org/10.7759/cureus.36331 | DOI Listing |
Front Oncol
January 2025
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Background: Breast cancer (BC), as a leading cause of cancer mortality in women, demands robust prediction models for early diagnosis and personalized treatment. Artificial Intelligence (AI) and Machine Learning (ML) algorithms offer promising solutions for automated survival prediction, driving this study's systematic review and meta-analysis.
Methods: Three online databases (Web of Science, PubMed, and Scopus) were comprehensively searched (January 2016-August 2023) using key terms ("Breast Cancer", "Survival Prediction", and "Machine Learning") and their synonyms.
Adv Sci (Weinh)
January 2025
State Key Laboratory of Synthetic Chemistry, Department of Chemistry, HKU-CAS Joint Laboratory on New Materials, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, 999077, P. R. China.
Color-tunable white organic light-emitting diodes (CT-WOLEDs) have attracted widespread attention given their large color variation to meet the different daily scenarios from the perspective of circadian rhythm. However, most reported CT-WOLEDs, especially the tri-color devices, exhibit poor performances and sophisticated structures. Here, a simple structure tri-color CT-WOLED is demonstrated that simultaneously exhibits high efficiency, ultralong operation lifetime, and wide color-tunable range for dynamic sunlight emulation.
View Article and Find Full Text PDFACS Nano
January 2025
Nanomedicine Research Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Pancreatic cancer therapies such as chemotherapy and immunotherapy are hindered by the dense extracellular matrix known as physical barriers, leading to heterogeneity impeding the effective penetration of chemotherapeutic agents and activation of antitumor immune responses. To address this challenge, we developed a hybrid nanoassembly with a distinct core-satellite-like heterostructure, PLAF@P/T-PD, which is responsive to both internal pH/redox and external ultrasound stimulations. This heterostructural nanoassembly features a polymersome core encapsulating an ultrasound contrast agent perfluoropentane and a chemotherapeutic agent Taxol (PLAF@P/T) electrostatically coated with satellite-like polyplexes carrying an immune agonist dsDNA (PD), which brings about synergistic functions inside the pancreatic tumor.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
Institute for Materials Discovery, University College London, London WC1E 7JE, U.K.
Paper is an ideal platform for creating flexible and eco-friendly electronic systems. Leveraging the synergistic integration of zero- and two-dimensional materials, it unfolds a broad spectrum of applications within the realm of the Internet of Things (IoT), spanning from wearable electronics to smart packaging solutions. However, for paper without a polymer coating, the rough and porous nature presents significant challenges as a substrate for electronics, and the absence of well-established fabrication methods further hinders its application in wearable electronics.
View Article and Find Full Text PDFRadiol Med
January 2025
Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Background: Accurate differentiation between benign and malignant pancreatic lesions is critical for effective patient management. This study aimed to develop and validate a novel deep learning network using baseline computed tomography (CT) images to predict the classification of pancreatic lesions.
Methods: This retrospective study included 864 patients (422 men, 442 women) with confirmed histopathological results across three medical centers, forming a training cohort, internal testing cohort, and external validation cohort.
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