AI Article Synopsis
- Liquid biopsies are becoming increasingly important in cancer detection and monitoring due to their minimally invasive nature, potential to replace traditional tissue biopsies, and ability to provide comprehensive information over time.
- They can identify various biomarkers, including proteomic, genomic, epigenetic, and metabolic changes, using single-omic and multi-omic techniques, which enhance understanding of disease evolution.
- The integration of these approaches could lead to more personalized medical care, allowing for better prognostic evaluations, early diagnosis, and tailored treatment plans for cancer patients.
Article Abstract
In the last years, liquid biopsy gained increasing clinical relevance for detecting and monitoring several cancer types, being minimally invasive, highly informative and replicable over time. This revolutionary approach can be complementary and may, in the future, replace tissue biopsy, which is still considered the gold standard for cancer diagnosis. "Classical" tissue biopsy is invasive, often cannot provide sufficient bioptic material for advanced screening, and can provide isolated information about disease evolution and heterogeneity. Recent literature highlighted how liquid biopsy is informative of proteomic, genomic, epigenetic, and metabolic alterations. These biomarkers can be detected and investigated using single-omic and, recently, in combination through multi-omic approaches. This review will provide an overview of the most suitable techniques to thoroughly characterize tumor biomarkers and their potential clinical applications, highlighting the importance of an integrated multi-omic, multi-analyte approach. Personalized medical investigations will soon allow patients to receive predictable prognostic evaluations, early disease diagnosis, and subsequent treatments.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10109350 | PMC |
| http://dx.doi.org/10.3389/fgene.2023.1152470 | DOI Listing |
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