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Progress on the effect of mutation on BMPR1B activity and BMP/SMAD pathway in sheep. | LitMetric
is the first major gene of litter size identified in sheep. However, the molecular mechanism of the mutation that increases the ovulation rate in sheep is still unclear. In recent years, it has been demonstrated that BMPR1B activity is regulated by the small molecule repressor protein FKBP1A, which acts as a key activity switch of the BMPR1B in the BMP/SMAD pathway. The mutation is located close to the binding site of FKBP1A and BMPR1B. In this review, we summarize the structure of BMPR1B and FKBP1A proteins, and clarify the spatial interactive domains of the two proteins with respect to the location of the mutation. Then the relationship between the mutation and the degree of affinity of the two proteins are predicted. Finally, the hypothesis that mutation causes change of activity in BMP/SMAD pathway by affecting the intensity of the interactions between BMPR1B and FKBP1A is proposed. This hypothesis provides a new clue to investigate the molecular mechanism of mutation affecting ovulation rate and litter size in sheep.
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