AI Article Synopsis
- The study aimed to analyze the transcriptional profiles of the pir multigene family in male and female gametocytes of Plasmodium chabaudi chabaudi from infected mice.
- Both male and female gametocytes transcribe unique sets of pir genes, demonstrating distinct patterns compared to their closely related species, P. berghei.
- The findings emphasize that while gametocyte-associated pir genes differ from those in chronic blood-stage infections, a specific male-associated pir gene has been identified as a potential area for further research.
Article Abstract
Objective: To analyse the transcriptional profiles of the pir multigene family of Plasmodium chabaudi chabaudi in male and female gametocytes isolated from the blood of infected mice.
Results: Infected red blood cells containing female and male P. chabaudi gametocytes transcribe a distinct set of genes encoded by the multigene family pir. The overall patterns are similar to what has been observed in the close relative P. berghei, but here we show that gametocyte-associated pir genes are distinct from those involved in chronic blood-stage infection and highlight a male-associated pir gene which should be the focus of future studies.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10114299 | PMC |
| http://dx.doi.org/10.1186/s13104-023-06322-1 | DOI Listing |
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