Background: Here we assessed a possible relationship between baseline TGF-β concentrations and acquisition of sterile immunity after Plasmodium falciparum sporozoite immunization.
Methods: TGF-β concentrations were determined in samples of 65 malaria-naive volunteers in 4 studies either prior to and after challenge infection, or prior to and after first immunizing infection under chemoprophylaxis with P. falciparum sporozoites.
Results: High baseline TGF-β concentrations were associated with rapid acquisition of sterile protection (p = 0.028).
Conclusion: Baseline TGF-β concentrations predict the efficiency of acquisition of sterile immunity following sporozoite immunization and may represent a steady-state regulatory mechanism to keep in check immune systems with a low threshold for activation.
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| http://dx.doi.org/10.1016/j.imlet.2023.04.005 | DOI Listing |
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