A series of isoxazoline derivatives containing diacylhydrazine moieties were designed and synthesized as potential insecticides. Most of these derivatives exhibited good insecticidal activities against , and some compounds exhibited excellent insecticidal activities against . Especially, showed outstanding insecticidal activity against (LC = 0.37 μg/mL), which was superior to that of ethiprole (LC = 2.84 μg/mL) and tebufenozide (LC = 15.3 μg/mL) and similar to that of fluxametamide (LC = 0.30 μg/mL). Remarkably, the insecticidal activity of against (LC = 1.72 μg/mL) was superior to that of chlorantraniliprole (LC = 3.64 μg/mL) and tebufenozide (LC = 60.5 μg/mL) but lower than that of fluxametamide (LC = 0.14 μg/mL). The results of electrophysiological experiments, molecular docking, and proteomics experiments indicate that compound acts by interfering with the γ-aminobutyric acid receptor to control pests.
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