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Vitiligo-like leukoderma following cyclin-dependent kinase 4/6 inhibitor treatment - systematic review of the literature.
Clin Exp Dermatol
March 2025
Division of Dermatology, Rabin Medical Center - Beilinson Hospital, Petach Tikva, Israel.
Background: Vitiligo-like leukoderma is being increasingly reported in patients with breast cancer treated with cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors.
Objective: The aim of the study was to systematically review the characteristics of CDK4/6 inhibitor-induced vitiligo-like leukoderma.
Methods: A comprehensive literature search was conducted to identify published cases of vitiligo-like leukoderma following CDK4/6 inhibitor therapy administered for advanced breast cancer.
Identifying potential biomarkers and molecular mechanisms related to arachidonic acid metabolism in vitiligo.
Front Mol Biosci
February 2025
Shaanxi Provincial Key Laboratory of Infection and Immune Diseases, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China.
Background: Numerous studies have reported that dysregulation of fatty acid metabolic pathways is associated with the pathogenesis of vitiligo, in which arachidonic acid metabolism (AAM) plays an important role. However, the molecular mechanisms of AAM in the pathogenesis of vitiligo have not been clarified. Therefore, we aimed to identify the biomarkers and molecular mechanisms associated with AAM in vitiligo using bioinformatics methods.
View Article and Find Full Text PDFAntithrombotic Effect of L. Extract and Its Fractions via Regulating TLRs and the Downstream MAPKs and PI3K/AKT Signaling Pathways in Zebrafish.
Int J Mol Sci
February 2025
Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong Province, Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), 28789 East Jingshi Road, Jinan 250103, China.
L., as a folkloric herb, is traditionally used to treat poisonous insect bites, vitiligo, and other ailments. However, its impact on thrombosis remains unknown.
View Article and Find Full Text PDFAn investigation into the mechanism for Kaempferol improving melanocyte death based on network Pharmacology and experimental verification.
Sci Rep
March 2025
Cosmetic dermatology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250000, China.
Melanocyte (MC) death represents the basic pathological change of vitiligo. Kaempferol (Kae) is one of the main active ingredients of Tribulus terrestris, which is a commonly used Chinese medicine in the treatment of vitiligo. However, it remains unclear whether Kae can improve MC death, and hence relevant mechanisms need to be further explored.
View Article and Find Full Text PDFValue of tacrolimus 0.1% in the treatment of vitiligo in the era of targeted therapy.
Ann Dermatol Venereol
March 2025
Centre of Evidence of the French Society of Dermatology, Paris, France; Montpellier University, Montpellier, France. Electronic address:
Background: Vitiligo, a prevalent depigmenting condition, affects both adults and children, significantly impacting their quality of life. The standard treatment approach involves the application of topical corticosteroids in conjunction with narrow-band ultraviolet B (UVB) phototherapy. A novel topical treatment, ruxolitinib (a Janus kinase inhibitor), has recently received approval.
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