In the wake of the emerging development of biologics in atopic dermatitis (AD), herpes zoster (HZ) infection has been reported as a treatment-related adverse event. This study aims at investigating the association between AD and HZ, and the risk factors within. 28,677 participants with AD from the Taiwan National Health Insurance Research Database 2000-2015 were enrolled. Risk of HZ infection was compared in the study cohort (with AD) and the control cohort (without AD). Further analyses were conducted in gender-, age-, and treatment strategy-stratified subgroups. Significantly higher adjusted hazard ratios (aHRs) of HZ infection were revealed in AD patients (aHR = 2.303,  < 0.001), and remained this trend in gender- and age-stratified models. All AD groups, irrespective of the treatment type, had higher aHRs (AD without systemic treatment: aHR = 2.356,  < 0.001; AD with systemic treatment: aHR = 2.182,  < 0.001) compared with those without AD. However, no differences in HZ risk were shown between each treatment type. Risk of HZ infection in AD is higher irrespective of treatment type. Considering that AD increases susceptibility to HZ infection, the administration of biologics requires careful considerations.

Download full-text PDF

Source
http://dx.doi.org/10.1089/derm.2022.0094DOI Listing

Publication Analysis

Top Keywords

atopic dermatitis
8
herpes zoster
8
zoster infection
8
dermatitis risk
4
risk factor
4
factor herpes
4
infection
4
infection independent
4
independent treatment
4
treatment nationwide
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!