AI Article Synopsis
- Biliary adenofibroma is a rare benign liver tumor that can lead to malignancy, as evidenced by a case involving a 64-year-old woman who developed intrahepatic cholangiocarcinoma from it.
- Imaging studies showed a 50 mm tumor with two distinct components, one resembling cholangiocarcinoma and the other fitting the description of biliary adenofibroma, requiring extended left hepatectomy for treatment.
- Preoperative identification of biliary adenofibroma is difficult, highlighting the importance of detecting any malignant indicators during diagnosis.
Article Abstract
Purpose: Biliary adenofibroma is a solid microcystic epithelial neoplasm in the liver, comprising microcystic and tubuloacinar glandular tissues lined by a non-mucin secreting biliary epithelium and supported by a fibrous stroma. It is an extremely rare benign tumor with potential for malignant transformation. Herein, we report the case of a 64-year-old woman diagnosed with intrahepatic cholangiocarcinoma arising from biliary adenofibroma.
Methods: Imaging studies revealed a tumor of 50 mm diameter, consisting of two components in S1 of the liver. The ventral portion of the tumor showed an ill-defined mass with early peripheral and gradual centripetal enhancement invading to the middle hepatic vein on computed tomography (CT), diffusion restriction on magnetic resonance images, and high fluorine-18-2-deoxy-D-glucose (FDG) uptake on positron emission tomography, like conventional intrahepatic cholangiocarcinoma. The dorsal portion showed a well-defined and low-attenuated mass with heterogeneous early enhancement and partial wash-out on CT, marked hyperintensity on heavily T2-weighted images, and low FDG uptake. The patient subsequently underwent extended left hepatectomy.
Results: Pathologically, the former was diagnosed as cholangiocarcinoma and the latter as biliary adenofibroma. We discuss the radiological-pathological correlation of the tumor with a literature review.
Conclusion: Preoperative diagnosis of biliary adenofibroma is extremely challenging; however, clinically, it is crucial not to miss the presence of malignant findings.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333138 | PMC |
| http://dx.doi.org/10.1007/s00261-023-03908-y | DOI Listing |
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