Total knee arthroplasty (TKA) has been the gold standard treatment for end stage arthritis of knee. The advancements in techniques have allowed successful outcomes. The use of closed negative suction drain in TKA has been controversial. Entrapment of a drain following TKA with a broken drain has been reported rarely though it has important implications. An obese 65-year-old female presented with painful bilateral knees. A clinic-radiological assessment confirmed an advanced grade osteoarthritis (OA). A single stage bilateral TKA was done. The use of closed negative suction drain for both knees was done as a routine protocol. The left knee drain got entrapped and an inadvertent pull due to abnormal positioning in flexed knee impinged and broke the drain. The right knee removal of drain on the second post-operative day was uneventful. A radiological assessment confirmed the position of the broken drain in left knee. A mini arthrotomy ensued with removal of the drain piece. Subsequent post-operative period was uneventful. The knee function recovered with painless full range of motion. There was no evidence of infection or implant loosening noted at a two-year follow-up. The generative text model ChatGPT (OpenAI, USA) was used to identify the implication with the use of drains in TKA. The use of drains remains controversial with no clear consensus on its regular use. The breakage of drain poses an immediate concern with need for wound revision and removal of foreign body. The long-term observation for any knee infection, stiffness or poor knee function needs monitoring. The early identification can prevent late symptomatology. The closed negative suction drain in our practice has become selective and presently has an infrequent use in TKA. An entrapment of a closed negative suction drain merits urgent measures. The remedial measures may ensure to preserve the knee joint function and maintain the ability to do activities of daily living.
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http://dx.doi.org/10.7759/cureus.36290 | DOI Listing |
Ann Behav Med
January 2025
Wroclaw Faculty of Psychology, SWPS University, Ostrowskiego 30b5, 53-238 Wroclaw, Poland.
Background: The close relationship processes and health model and the dyadic health influence model posit that relationship beliefs (eg, relationship satisfaction) and influence strategies (eg, provision and receipt of positive and negative social control) mediate health behavior change. However, evidence for such mediation in parent-child dyads is limited.
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Sci Rep
January 2025
Xiyuan Hospital, China Academy of Chinese Medicine Sciences, Beijing, 100091, China.
Identifying dependable prognostic indicators is essential for the efficient management of metabolic dysfunction-associated steatotic liver disease (MASLD). The index of hemoglobin glycation (HGI) has been demonstrated to be closely linked to the onset and advancement of MASLD. Currently, no studies have investigated the relationship between HGI and mortality rates among MASLD patients.
View Article and Find Full Text PDFNat Commun
January 2025
Center for Integrative Genomics, University of Lausanne, Faculty of Biology and Medicine, Lausanne, Switzerland.
The energetic demands of proliferating cells during tumorigenesis require close coordination between the cell cycle and metabolism. While CDK4 is known for its role in cell proliferation, its metabolic function in cancer, particularly in triple-negative breast cancer (TNBC), remains unclear. Our study, using genetic and pharmacological approaches, reveals that CDK4 inactivation only modestly impacts TNBC cell proliferation and tumor formation.
View Article and Find Full Text PDFJ Phys Chem B
January 2025
Homi Bhabha National Institute, Anushakti Nagar, Mumbai 400094, India.
Introduction of non-DLVO forces by nonionic surfactants brings about fascinating changes in the phase behavior of silica nanosuspensions. We show here that alterations in the interaction and wetting properties of negatively charged silica nanoparticles (Ludox® LS) in the presence of polyethylene oxide-polypropylene oxide-polyethylene oxide-based triblock copolymers called Pluronics lead to the formation of stable o/w Pickering emulsions and interparticle attraction-induced thermoresponsive liquid-liquid phase separations. The results make interesting comparisons with those reported for Ludox® TM nanosuspensions comprising larger silica nanoparticles.
View Article and Find Full Text PDFZhong Nan Da Xue Xue Bao Yi Xue Ban
July 2024
Department of Neurology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Objectives: The prevalence of Alzheimer's disease (AD) is increasing globally, however its pathogenesis is still unclear. The evidence showed that the progression of AD was closely related to the apoptosis of nerve cells. This study amis to explore the role and specific mechanism of miR-15a and Bag5 in the apoptosis of nerve cells induced by beta-amyloid protein (Aβ) in AD.
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