The influence of acetylsalicylic acid (ASA) and naproxen on the biochemical properties of intact growing femora in young male rats was studied. The medication periods were 9 and 18 days. At an ASA dose of 150 mg/kg/12 h the rate of collagen synthesis and the rate of mineral incorporation decreased and were impaired by about 10% compared with controls after 18 days. The dry weights and contents of collagen and calcium were not influenced after 9 days, but were reduced by 4%-7% after 18 days. A higher solubility of collagen (7%) was also found at the end of the study. In rats that received ASA at 100 mg/kg/12 h no significant differences were observed. A naproxen dose of 20 mg/kg/12 h reduced the rate of mineral deposition after 18 days, but had no other detectable effects on bone. The results indicate that ASA inhibits bone formation.
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