AI Article Synopsis

  • The study investigates factors influencing local recurrence-free survival (LRFS) in patients with retroperitoneal liposarcoma (RPLS) who underwent surgery, identifying key characteristics that correlate with outcomes.
  • Out of 348 RPLS cases analyzed, a significant 88.9% experienced tumor recurrence, with a median LRFS duration of 17 months.
  • Key predictors for poor LRFS were found to be high preoperative neutrophil/lymphocyte ratio (NLR), repeat surgeries, long operation times, irregular tumor shapes, poorly differentiated histological subtypes, and tumor necrosis, leading to the development of a predictive nomogram.

Article Abstract

Background: As the leading cause of mortality for retroperitoneal liposarcoma (RPLS) cases, postoperative recurrence has complicated and unclear risk factors. This study was conducted to explore the correlations between demographic, surgical, and pathological characteristics with local recurrence-free survival (LRFS) for surgical resected RPLS.

Methods: RPLS cases that underwent radical operation were considered to be included in this analysis. LRFS rates were estimated based on the Kaplan-Meier method and were compared between groups by the log-rank test. Cox proportional hazard regression models were constructed to identified the predictors of LRFS. Subsequently, the independent predictors acquired from multivariate analyses were used to construct a nomogram.

Results: 348 RPLS cases who underwent radical operation were included. Of the 348 cases, 333 had tumor recurrence or with a follow-up period ≥5 years. Thus, 296 (88.9%) of the 333 cases had recurrent disease, and the median LRFS duration of 296 recurrence cases was 17.0 (95% confidence interval (CI) 13.2-20.8) months. Multivariate analysis identified the preoperative neutrophil/lymphocyte ratio (NLR), surgical frequency, operative time, tumor shape, histological subtype, and tumor necrosis as independent predictors of LRFS. Based on above independent predictors, a nomogram was constructed to predict the 1-, 3-, and 5-year LRFS of surgical resected RPLS.

Conclusion: Elevated preoperative NLR, ≥2nd time surgical frequency, extended operation time, irregular tumor shape, no well-differentiated histological subtype, and tumor necrosis could be used as predictors of LRFS for surgical resected RPLS.

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http://dx.doi.org/10.1007/s00268-023-07009-1DOI Listing

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