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File: /var/www/html/index.php
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Filename: controllers/Detail.php
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File: /var/www/html/application/controllers/Detail.php
Line: 249
Function: _error_handler
File: /var/www/html/index.php
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File: /var/www/html/application/controllers/Detail.php
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Filename: controllers/Detail.php
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Filename: models/Detail_model.php
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Function: insertAPISummary
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As a copper (Cu) transport ATPase, ATP7B plays an important role in maintaining Cu homeostasis in the body and its dysfunction is associated with retinal disease. How ATP7B dysfunction and the subsequent Cu overload induce retinal damage, however, are unknown. Here, we show that atp7b-/- homozygous zebrafish larvae are insensitive to light stimulation, with a reduction in retinal cells but normal like morphological phenotypes. Additionally, a series of differentially expressed genes are unveiled in atp7b-/- mutated larvae, which enrich in photo-transduction, structural constituent of eye lens, sensory perception of light stimulus, oxidative phosphorylation, and ATPase activity. Moreover, we show the Cu accumulation in retinal cells in atp7b-/- mutated larvae, which results in endoplasmic reticulum (ER) stress and retinal cell apoptosis and subsequent retinal defects. The integral data in this study demonstrate that atp7b mutation leads to Cu accumulation in zebrafish retinal cells and the consequence ER stress and retinal cell death. These data may give some possible hints to explain retinal disease occurred in the Cu dysregulation syndromes Wilson's disease with ATP7B mutation.
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http://dx.doi.org/10.1093/mtomcs/mfad024 | DOI Listing |
Front Mol Neurosci
December 2024
Pennsylvania College of Optometry, Salus at Drexel University, Elkins Park, PA, United States.
Retinal membrane guanylyl cyclase (RetGC), regulated by guanylyl cyclase activating proteins (GCAPs) via negative calcium-feedback, is one of the most critically important enzymes in vertebrate rod and cone physiology, enabling their sensitivity to light. It was also reported that, similarly to olfactory receptor guanylyl cyclase, bicarbonate anion directly stimulates RetGC activity in photoreceptors as a novel phototransduction-linked regulating factor. We directly tested whether or not RetGC is a bicarbonate-activated enzyme using recombinant human RetGC expressed in HEK293 cells and the native RetGC in mouse retinas.
View Article and Find Full Text PDFData Brief
December 2024
Purdue University, 610 Purdue Mall, West Lafayette, IN 47907, United States.
Cone and spectral opponency are fundamental to colour processing in many species and are well studied in primates. The data required to make interspecific comparisons of the neural mechanisms associated with colour processing is spread across a broad body of literature reaching back to the 1950's across four retinal cell types and multiple brain regions. We aimed to produce a comprehensive dataset of all known cone opponent cells in non-primate vertebrates in image forming visual pathways.
View Article and Find Full Text PDFExp Eye Res
December 2024
Department of Ophthalmology, the Second Hospital of Jilin University, Changchun, Jilin Province, China. Electronic address:
The number of people suffering from type 2 diabetes (DM2) is increasing and over 30 percent of DM2 patients will develop diabetic retinopathy (DR). Available therapeutic approaches for DR have their limitations. It is of great significance to search for other effective alternate therapeutic approaches.
View Article and Find Full Text PDFJ Ethnopharmacol
December 2024
College of Traditional Chinese Medicine, Heilongjiang University of Chinese Medical, Heping Road, Harbin 150030, China. Electronic address:
Ethnopharmacological Relevance: Cortex Dictamni (CD) is the dried root skin of Dictamnus dasycarpus Turcz, widely used in the field of traditional Chinese medicine. Recent adverse reactions to CD limited the clinical application in combination with other traditional Chinese medicines.
Aim Of The Study: To investigate the retinitis pigmentosa (RP) effects of CD using the zebrafish model and elucidate the underlying molecular mechanism of CD-induced RP in zebrafish.
Function (Oxf)
December 2024
Department of Anatomy, College of Medicine, The Catholic University of Korea, Seoul, Korea.
During retinal visual processing, rod bipolar cells (RBC) transfer scotopic signals from rods to AII amacrine cells as second-order neurons. Elucidation of the RBC's excitation/inhibition is essential for understanding the visual signal transmission. Excitation mechanisms via mGluR6 and voltage-gated Ca2+ channels in the RBCs and GABAergic inhibitory synaptic inputs have been studied in previous studies.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!