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| http://dx.doi.org/10.1161/CIRCHEARTFAILURE.123.010419 | DOI Listing |
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Similarities and Differences Between Bullying and Sexual Harassment in Schools: A Social-Ecological Review of Risk and Protective Factors.
Behav Sci (Basel)
January 2025
L. Douglas Wilder School of Government and Public Affairs, Virginia Commonwealth University, Richmond, VA 23284, USA.
In this conceptual article, the authors provide a narrative review of literature on bullying and sexual harassment in K-12 schools framed through a comparative analysis of risk and protective factors for both forms of violence across the social-ecological spectrum. We find that a greater number of studies of both forms of violence focus on student and microsystem-level factors rather than on higher levels of the ecosystem including school boards, neighborhoods, and broader cultural norms. In addition, the research overwhelmingly identifies more risk factors than protective factors.
View Article and Find Full Text PDFDiagnostic and Therapeutic Microbial Circuit with Application to Intestinal Inflammation.
ACS Synth Biol
December 2024
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125, United States.
Bacteria genetically engineered to execute defined therapeutic and diagnostic functions in physiological settings can be applied to colonize the human microbiome, providing in situ surveillance and conditional disease modulation. However, many engineered microbes can only respond to single-input environmental factors, limiting their tunability, precision, and effectiveness as living diagnostic and therapeutic systems. For engineering microbes to improve complex chronic disorders such as inflammatory bowel disease, the bacteria must respond to combinations of stimuli in the proper context and time.
View Article and Find Full Text PDFPractice Patterns of Liver Allograft Acceptance From Donors After Circulatory Death at US Transplant Centers.
Transplant Proc
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Department of Surgery, Division of Transplant and Hepatobiliary Surgery, UC San Diego, San Diego, California.
Background: United States transplant centers have low rates of liver allograft utilization from donation after circulatory death (DCD) donors. Prolonged functional donor warm ischemic time (f-DWIT) is associated with worse outcomes; however, center practices regarding f-DWIT are unclear. As emerging technologies are changing the landscape of DCD liver transplantation, this study aims to gain insights into the practices of US centers around DCD liver allograft utilization.
View Article and Find Full Text PDFThe Spatial Structure of the Tumor Immune Microenvironment Can Explain and Predict Patient Response in High-Grade Serous Carcinoma.
Cancer Immunol Res
November 2024
Department of Computer Science, University of Colorado, Boulder, Colorado.
Ovarian cancer is the deadliest gynecologic malignancy, and therapeutic options and mortality rates over the last three decades have largely not changed. Recent studies indicate that the composition of the tumor immune microenvironment (TIME) influences patient outcomes. To improve spatial understanding of the TIME, we performed multiplexed ion beam imaging on 83 human high-grade serous carcinoma tumor samples, identifying approximately 160,000 cells across 23 cell types.
View Article and Find Full Text PDFDemonstration of Tunable Control over a Delayed-Release Vaccine Using Atomic Layer Deposition.
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VitriVax, Inc., 5435 Airport Blvd Suite 106, Boulder, CO 80301, USA.
Many vaccines require multiple doses for full efficacy, posing a barrier for patient adherence and protection. One solution to achieve full vaccination may be attained with single-administration vaccines containing multiple controlled release doses. In this study, delayed-release vaccines were generated using atomic layer deposition (ALD) to coat antigen-containing powders with alumina.
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