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Vaccines and therapeutics for immunocompromised patients with COVID-19. | LitMetric

AI Article Synopsis

  • The COVID-19 pandemic has had a greater negative impact on immunocompromised patients, leading to higher risks of severe disease and complications.
  • Individuals with weakened immune systems, such as transplant recipients and those with blood cancers, often struggle with vaccine responses and face prolonged hospitalizations.
  • There is a significant lack of data on effective vaccination and treatment strategies specifically for immunocompromised individuals, as most clinical trials have not included enough participants from this group.

Article Abstract

The COVID-19 pandemic has disproportionately impacted immunocompromised patients. This diverse group is at increased risk for impaired vaccine responses, progression to severe disease, prolonged hospitalizations and deaths. At particular risk are people with deficiencies in lymphocyte number or function such as transplant recipients and those with hematologic malignancies. Such patients' immune responses to vaccination and infection are frequently impaired leaving them more vulnerable to prolonged high viral loads and severe complications of COVID-19. Those in turn, have implications for disease progression and persistence, development of immune escape variants and transmission of infection. Data to guide vaccination and treatment approaches in immunocompromised people are generally lacking and extrapolated from other populations. The large clinical trials leading to authorisation and approval of SARS-CoV-2 vaccines and therapeutics included very few immunocompromised participants. While experience is accumulating, studies focused on the special circumstances of immunocompromised patients are needed to inform prevention and treatment approaches.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10091856PMC
http://dx.doi.org/10.1016/j.eclinm.2023.101965DOI Listing

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