Background And Objectives: The misuse of antibiotics in recent years has led to an increase in antibiotic associated diarrheas (AAD). Out of several implicated pathogens, is responsible for causing 15-25% of all cases of AAD. However, it has remained under diagnosed for a long time. The current study is planned to explore prevalence of amongst AAD patients and to study clinical presentation and associated risk factors.
Materials And Methods: Hospital based cross sectional study conducted in patients above 2 years of age. Diagnosis of was done by two modalities i.e. glutamate dehydrogenase test followed by toxin detection using enzyme immunoassay and stool culture followed by toxin gene detection.
Results: Twelve of 65 patients (18.4%) were positive for Maximum cases were found in younger age group. Abdominal pain and fever were most common complaints. 12 (18.4%) out of 65 study subjects were found to be positive by ELISA. 2/65 (3%) patients were positive for culture with presence of only gene. Ceftriaxone was the most commonly used antibiotic (25%).
Conclusion: is significant pathogen implicated in AAD with a prevalence rate of 18.4%. GDH antigen detection followed by Toxin A/B ELISA for yielded better detection rate as compared to stool culture.
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| http://dx.doi.org/10.18502/ijm.v15i1.11918 | DOI Listing |
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