AI Article Synopsis
- This study focuses on the azole-resistant strains of a fungus that causes infections in head and neck cancer patients, aiming to uncover their resistance mechanisms and virulence factors.
- Researchers collected 38 clinical isolates to assess antifungal susceptibility, evaluate gene expression levels, and analyze virulence attributes like protease activity and biofilm formation.
- The findings revealed fluconazole resistance in some isolates, increased expression of specific genes, and overall high pathogenicity, while voriconazole was noted as an effective antifungal treatment.
Article Abstract
Background And Objectives: is one of the major non- species causing nosocomial infection. There is limited data about mechanisms of azole-resistance and virulence factors of . This study was designed to investigate molecular mechanism of azole-resistance and major virulence factors of isolated from oropharyngeal candidiasis in head and neck cancer patients.
Materials And Methods: After collecting 38 clinical isolates, antifungal susceptibility pattern and the expression levels of and were evaluated. Moreover, proteinase and phospholipase activity and biofilm formation of the isolates were investigated as virulence factors.
Results: We detected fluconazole resistance in 7 isolates. The expression levels of and were increased respectively. Protease activity and biofilm formation were seen in all isolates. Five isolates did not exhibit phospholipase activity.
Conclusion: Taken together, the overexpressions of and genes were found in fluconazole resistant , isolated from oropharyngeal candidiasis patients. Also, voriconazole was an effective antifungal against isolates. The observed high protease enzyme activity and biofilm formation suggested strong pathogenicity of these isolates.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10105282 | PMC |
| http://dx.doi.org/10.18502/ijm.v15i1.11933 | DOI Listing |
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