AI Article Synopsis

  • The study aimed to explore whether exposure to PFAS (perfluorinated alkyl substances) is linked to increased body weight during a dietary intervention.
  • In a trial with 381 participants, higher plasma levels of two key PFAS (PFOA and PFHxS) were correlated with significant weight gain over 26 weeks, even after adjusting for dietary differences and gender.
  • The findings suggest that certain PFAS may promote weight gain, indicating they could play a role in the obesity crisis.

Article Abstract

Objective: The purpose of this study was to test the hypothesis that perfluorinated alkylate substance (PFAS) exposures are associated with body weight increases in a dietary intervention study.

Methods: In the DioGenes trial, adults with obesity first lost at least 8% of their body weight and then completed at least 26 weeks on a specific diet. Concentrations of five major PFASs were assessed in plasma samples from study baseline.

Results: In 381 participants with complete data, plasma concentrations averaged 2.9 ng/mL and 1.0 ng/mL for perfluorooctanoic acid (PFOA) and perfluorohexanesulfonic acid (PFHxS), respectively. A doubling in plasma PFOA was associated with an increase in weight at 26 weeks by 1.50 kg (95% CI: 0.88-2.11), with an increase of 0.91 kg (95% CI: 0.54-1.27) for PFHxS, independent of diet groups and sex. Associations for other PFASs were in the same direction and significant, although not after adjustment for PFOA and PFHxS. Weight changes associated with elevated PFAS exposures were similar to or larger than average changes ascribed to the different diet groups.

Conclusions: Elevated plasma concentrations of PFOA and PFHxS were associated with increased weight gain that exceeded those related to the diets. Obesogenic PFASs may cause weight gain and thus contribute to the obesity pandemic.

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http://dx.doi.org/10.1002/oby.23755DOI Listing

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