Objective: The purpose of this study was to test the hypothesis that perfluorinated alkylate substance (PFAS) exposures are associated with body weight increases in a dietary intervention study.
Methods: In the DioGenes trial, adults with obesity first lost at least 8% of their body weight and then completed at least 26 weeks on a specific diet. Concentrations of five major PFASs were assessed in plasma samples from study baseline.
Results: In 381 participants with complete data, plasma concentrations averaged 2.9 ng/mL and 1.0 ng/mL for perfluorooctanoic acid (PFOA) and perfluorohexanesulfonic acid (PFHxS), respectively. A doubling in plasma PFOA was associated with an increase in weight at 26 weeks by 1.50 kg (95% CI: 0.88-2.11), with an increase of 0.91 kg (95% CI: 0.54-1.27) for PFHxS, independent of diet groups and sex. Associations for other PFASs were in the same direction and significant, although not after adjustment for PFOA and PFHxS. Weight changes associated with elevated PFAS exposures were similar to or larger than average changes ascribed to the different diet groups.
Conclusions: Elevated plasma concentrations of PFOA and PFHxS were associated with increased weight gain that exceeded those related to the diets. Obesogenic PFASs may cause weight gain and thus contribute to the obesity pandemic.
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http://dx.doi.org/10.1002/oby.23755 | DOI Listing |
J Phys Chem A
December 2024
Chemical Sciences and Engineering Division, Argonne National Laboratory, Lemont, Illinois 60439, United States.
Radical-radical reaction channels are important in the pyrolysis and oxidation chemistry of perfluoroalkyl substances (PFAS). In particular, unimolecular dissociation reactions within unbranched -perfluoroalkyl chains, and their corresponding reverse barrierless association reactions, are expected to be significant contributors to the gas-phase thermal decomposition of families of species such as perfluorinated carboxylic acids and perfluorinated sulfonic acids. Unfortunately, experimental data for these reactions are scarce and uncertain.
View Article and Find Full Text PDFJ Hazard Mater
December 2024
Department of Chemical and Biomolecular Engineering, 8 Clarkson Avenue, Clarkson University, Potsdam, NY 13699, USA. Electronic address:
This work used pulsed electrical discharge plasma to treat undiluted Aqueous Film Forming Foam (AFFF) solution that contained significant quantities of per- and polyfluoroalkyl substances (PFAS). The plasma was generated within a plasma spinning disc reactor (PSDR), which utilizes the electric breakdown of argon gas to create plasma over a thin liquid film generated on a spinning disc. The PSDR performance toward degradation of AFFF constituents such as fluorotelomers, perfluorinated C-C alkyl acids, and unidentified precursors was investigated.
View Article and Find Full Text PDFSci Total Environ
December 2024
Flemish Institute for Technological Research (VITO), Unit Materials and Chemistry (MATCH), 2400 Mol, Belgium.
Chemistry
November 2024
Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustrasse 3, 14195, Berlin, Germany.
The self-assembly process is governed by the individual constituents of molecules through precise non-covalent interactions. Amphiphilic cyanines are intriguing in supramolecular chemistry due to the large polarizability of their delocalized π-electron systems, their tuneable optical properties and their ability to form well-defined self-assembled structures in different media. Here we present the synthesis of a novel tetrahydroxy amphiphilic carbocyanine dye with perfluoro alkylated chains -(CH)-(CF)-CF as hydrophobic segments and aminoproanediol as hydrophilic segment.
View Article and Find Full Text PDFWater Res
January 2025
State Key Joint Laboratory of Environment Simulation and Pollution Control (SKLESPC), Beijing Key Laboratory for Emerging Organic Contaminants Control, School of Environment, Tsinghua University, Beijing 100084, China; Research Division for Wastewater Pollution and Carbon Reduction, Sichuan Energy Internet Research Institute, Tsinghua University, 610213, China. Electronic address:
Anion exchange resin (AER) adsorption is an effective technology for the removal of per- and polyfluoroalkyl substances (PFAS) from wastewater. However, existing AERs with tributylamine functional groups have poor adsorption selectivity for perfluorinated carboxylic acids (PFCAs) and 6:2 fluorotelomer sulfonate (6:2 FTS), and the structure-selectivity relationship is still unclear. In this study, several novel gel AERs with long-chain amine groups were prepared.
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