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The endocannabinoid N-arachidonoylethanolamine (AEA) is a pro-homeostatic bioactive lipid known for its anti-inflammatory, anti-oxidative, immunomodulatory, and neuroprotective properties, which may contrast/mitigate Alzheimer's disease (AD) pathology. This study explores the therapeutic potential of targeting fatty acid amide hydrolase (FAAH), the major enzyme degrading AEA, in mouse models of amyloidosis (APP/PS1 and Tg2576). Enhancing AEA signaling by genetic deletion of FAAH delayed cognitive deficits in APP/PS1 mice and improved cognitive symptoms in 12-month-old AD-like mice.
View Article and Find Full Text PDFMomentary physical activity, subjective age, and the moderating role of pain.
Eur J Ageing
January 2025
Department of Behavioral and Cognitive Sciences, Faculty of Humanities, Education and Social Sciences, University of Luxembourg, Campus Belval, 11, Porte des Sciences, L-4366, Esch-sur-Alzette, Luxembourg.
Subjective age, that is felt age compared to chronological age, is an important predictor of health and well-being in later life. It can fluctuate from day to day and from one moment to another. Previous cross-sectional and macro-longitudinal studies have shown that feeling younger is related to physical fitness and exercise.
View Article and Find Full Text PDFTaurine protection attenuates bisphenol-A-induced behavioral, neurochemical, and histopathological alterations in male rats.
Naunyn Schmiedebergs Arch Pharmacol
January 2025
Zoology Department, Faculty of Science, Cairo University, Giza, Egypt.
Due to the continuous exposure to bisphenol-A (BPA), the current study was conducted to evaluate taurine's neuroprotective action against BPA's adverse effect on the brain. Rats were grouped into control, BPA-treated rats, and taurine + BPA-treated rats. At the end of the 35-day treatment period, the memory of the rats was evaluated using the novel object test and the Y-maze test.
View Article and Find Full Text PDFTreadmill Exercise Mitigates Alzheimer's Pathology by Modulating Glial Polarization and Reducing Oligodendrocyte Precursor Cell Perivascular Clustering.
Med Sci Sports Exerc
January 2025
School of Physical Education and Sports Science, South China Normal University, Guangzhou, CHINA.
Purpose: This study aimed to investigate the pathological responses of glial cells at different distances from amyloid plaques and the characteristics of oligodendrocyte precursor cells (OPCs) in perivascular clustering. Additionally, it sought to explore the impact of exercise training on AD pathology, specifically focusing on the modulation of glial responses and the effects of OPC perivascular clustering.
Methods: Three-month-old C57BL/6 and APP/PS1 mice were divided into four groups: wild-type sedentary, wild-type exercise, sedentary AD, and exercise AD groups.
Effects of Phytoncide Inhalation on Stroop Task Performance in Patients with Mild Cognitive Impairment: An fNIRS Pilot Study.
Clin Psychopharmacol Neurosci
February 2025
Mind-Neuromodulation Laboratory, College of Medicine, Hallym University, Chuncheon, Korea.
Objective: : Several studies have reported the therapeutic effects of phytoncides on various mental disorders. However, little is known about the therapeutic effects of phytoncides on mild cognitive impairment (MCI), a prodromal stage of dementia. In this pilot study, we aimed to clarify the effect of inhaled phytoncides on the cognitive function of patients clinically diagnosed with MCI.
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