AI Article Synopsis
- Smoking is a significant risk factor for pulmonary metastasis in many cancers, but a study on pancreatic ductal adenocarcinoma (PDAC) examined its impact specifically.
- A retrospective case-control study compared 53 patients with lung metastases after PDAC surgery to 106 controls without, revealing that smoking rates were similar in both groups (47% each).
- The findings suggest that smoking does not increase the risk of lung metastases in resectable PDAC, highlighting the need for further research into other factors that may influence metastasis.
Article Abstract
Smoking is a risk factor for pulmonary metastasis in various malignancies. We investigated this association for pancreatic ductal adenocarcinoma (PDAC). We conducted a retrospective 1:2 case-control study of consecutive patients who underwent PDAC resection (2011-2021). Cases ultimately developed lung metastases and controls did not. Of 744 patients we identified 53 cases and 106 matched controls. Twenty-five (47%) cases and 50 (47%) matched controls had a history of smoking ( = 1.0). This indicates that smoking is not associated with increased risk of pulmonary metastasis in resectable PDAC. Further research is needed to elucidate tumor and parenchymal factors influencing metastatic site.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10876288 | PMC |
| http://dx.doi.org/10.1080/07357907.2023.2203747 | DOI Listing |
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