Chem Commun (Camb)
Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea.
Published: May 2023
A paired electrochemical method is presented for the one-pot synthesis of γ,δ-unsaturated α-amino esters. The method involves the generation of organozinc reagents through zinc chloride reduction on the nickel cathode and the TEMPO-mediated oxidation of amino esters on the carbon anode. The presence of an ester moiety in the amine substrate was found to be crucial for achieving high diastereoselectivity.
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http://dx.doi.org/10.1039/d3cc01197f | DOI Listing |
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