Effect of coronaviruses on blood vessel permeability: potential therapeutic targets.

Ther Adv Respir Dis

Laboratory of Vascular Nanopharmacology, Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes, 1524, ICB I, sala 319, 3° andar, Butantan, Sao Paulo 05508-900, Brazil.

Published: April 2023

Coronavirus-induced diseases have afflicted humanity for several decades. This scenario was aggravated by the emergence of the coronavirus disease 2019 (named COVID-19) in Wuhan, China, in December 2019. Since then, COVID-19 has killed millions of people worldwide, probably the most devastating pandemic since HIV/AIDS. This review aimed to bring together important updated aspects related to coronavirus-induced diseases and the enhanced vascular permeability observed mainly in the lungs of affected people. The dysregulated vascular permeability in the lungs is of fundamental importance for coronaviruses-caused morbidity and mortality. Thus, as described in this review, it is a target of new and old drugs.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10111163PMC
http://dx.doi.org/10.1177/17534666231162252DOI Listing

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