AI Article Synopsis
- The study investigates the role of bone morphogenetic protein (BMP) signaling in the early development of taste papillae, highlighting the necessity of the mesenchymal tissue in the tongue for proper taste cell differentiation.
- Researchers utilized a mesenchyme-specific knockout model and found that the absence of certain BMP signaling led to a failure in the formation of taste papillae at embryonic day 12.0 (E12.0).
- Through RNA sequencing and other analyses, the study identified that the mesenchymal component of the tongue controls key differentiating factors in taste cell development, establishing new insights into taste papilla formation.
Article Abstract
Unlabelled: Taste papillae are specialized organs each of which is comprised of an epithelial wall hosting taste buds and a core of mesenchymal tissue. In the present study, we report that during the early stages of embryonic development, bone morphogenetic protein (BMP) signaling mediated by type 1 receptor ALK3 in the tongue mesenchyme is required for the epithelial Wnt/β-catenin activity and taste papilla cell differentiation. Mesenchyme-specific knockout ( ) of using and resulted in an absence of taste papillae at E12.0. Biochemical and cell differentiation analyses demonstrated that mesenchymal ALK3-BMP signaling governs the production of previously unappreciated secretory proteins, i.e., suppresses those that inhibiting and facilitates those promoting taste cell differentiation. Bulk RNA-Sequencing analysis revealed many more differentially expressed genes (DEGs) in the tongue epithelium than in the mesenchyme in vs control. Moreover, we detected a down-regulated epithelial Wnt/β-catenin signaling, and taste papilla development in the was rescued by GSK3β inhibitor LiCl, but not Wnt3a. Our findings demonstrate for the first time the requirement of tongue mesenchyme in taste papilla cell differentiation.
Summary Statement: This is the first set of data to implicate the requirement of tongue mesenchyme in taste papilla cell differentiation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10103976 | PMC |
| http://dx.doi.org/10.1101/2023.04.03.535414 | DOI Listing |
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