AI Article Synopsis

  • Van Wyk Grumbach syndrome (VWGS) is a condition characterized by isosexual precocious puberty and ovarian masses, often linked to long-standing juvenile hypothyroidism.
  • A case study of a 4-year-old girl highlights the syndrome's presentation, which included non-traumatic vaginal bleeding and thyroid dysfunction.
  • The report emphasizes the importance of recognizing clinical and imaging features of VWGS for prompt diagnosis and treatment to prevent complications.

Article Abstract

Unlabelled: Isosexual precocious puberty with ovarian masses in long-standing juvenile hypothyroidism is well described in the literature as Van Wyk Grumbach syndrome (VWGS). The present case reports this rare entity in a 4-year-old girl who was referred for imaging to evaluate the cause of non-traumatic bleeding per vagina. Antecedent history, clinical features and thyroid function tests were consistent with long-standing juvenile hypothyroidism with documented clinical response to thyroxine replacement therapy.

Contribution: Typical clinical and radiological features of the syndrome are reported, which helps in the early diagnosis and management, henceforth avoiding the associated complications.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10091148PMC
http://dx.doi.org/10.4102/sajr.v27i1.2572DOI Listing

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