AI Article Synopsis
- Kidney transplant recipients (KTRs) remain at high risk for severe COVID-19, necessitating booster vaccinations and monoclonal antibody treatments for better protection.
- A study found that only 46% of vaccinated KTRs could neutralize various SARS-CoV-2 variants, with many showing poor response to Omicron variants.
- Tixagevimab/cilgavimab showed limited effectiveness, especially against newer Omicron strains, highlighting the need for improved strategies for protecting KTRs from COVID-19.
Article Abstract
Introduction: Kidney transplant recipients (KTRs) are at high risk of severe COVID-19, even when they are fully vaccinated. Additional booster vaccinations or passive immunization with prophylactic monoclonal antibodies are recommended to increase their protection against severe COVID-19.
Methods: Here, we describe the neutralization of SARS-CoV-2 Delta, Omicron BA.1, BA.2, BA.4, and BA.5 variants, firstly by 39 serum samples from vaccinated KTRs exhibiting anti-spike antibody concentrations ≥264 binding antibody units (BAU)/mL and, secondly, by tixagevimab/cilgavimab.
Results: No neutralization was observed for 18% of the KTRs, while serum from only 46% of patients could neutralize the five variants. Cross-neutralization of the Delta and Omicron variants occurred for 65-87% of sera samples. The anti-spike antibody concentration correlated with neutralization activity for all the variants. The neutralization titers against the Delta variant were higher in vaccinated KTRs who had previously presented with COVID-19, compared to those KTRs who had only been vaccinated. Breakthrough infections occurred in 39% of the KTRs after the study. Tixagevimab/cilgavimab poorly neutralizes Omicron variants, particularly BA.5, and does not neutralize BQ.1, which is currently the most prevalent strain.
Discussion: As a result, sera from seropositive vaccinated KTRs had poor neutralization of the successive Omicron variants. Several Omicron variants are able to escape tixagevimab/cilgavimab.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095161 | PMC |
| http://dx.doi.org/10.3389/fmicb.2023.1147455 | DOI Listing |
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