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| http://dx.doi.org/10.1002/aet2.10866 | DOI Listing |
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CK2B Induces CD8 T-Cell Exhaustion through HDAC8-Mediated Epigenetic Reprogramming to Limit the Efficacy of Anti-PD-1 Therapy in Non-Small-Cell Lung Cancer.
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Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, 300060, China.
Anti-PD-1 therapy has left an indelible mark in the field of non-small-cell lung cancer (NSCLC) treatment; however, its efficacy is limited in clinical practice owing to differences in the degree of effector T-cell exhaustion. Casein kinase 2 (CK2) is a protein kinase that plays an important role in T-cell immunity. In this study, it is aimed to explore the potential of targeting CK2 and its regulatory subunit CK2B to prevent or reverse T-cell exhaustion, thereby enhancing the efficacy of anti-PD-1 therapy in NSCLC.
View Article and Find Full Text PDFWoodbury Storer How (1829-1911): the man and his plier.
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The eponymously named How plier has been used as an orthodontic utility plier for over a century. Woodbury Storer How was in fact not an orthodontist but a general dentist, who used the plier as an integral instrument for his crown technique. Its currency today is due to its adoption by Edward Hartley Angle, who left his indelible mark on the development of orthodontics.
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Department of Nursing, Huzhou University, Huzhou, Zhejiang, China.
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Department of Periodontology, Goethe University Frankfurt/Main, Center for Dentistry and Oral Medicine (Carolinum), Frankfurt am Main, Germany.
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