Background: Recent years have witnessed the advancement of deep learning vision technologies and applications in the medical industry. Intelligent devices for specific medication management could alleviate workload of medical staff by providing assistance services to identify drug specifications and locations.
Methods: In this work, object detectors based on the you only look once (YOLO) algorithm are tailored for toxic and narcotic medication detection tasks in which there are always numerous of arbitrarily oriented small bottles. Specifically, we propose a flexible annotation process that defines a rotated bounding box with a degree ranging from 0° to 90° without worry about the long-short edges. Moreover, a mask-mapping-based non-maximum suppression method has been leveraged to accelerate the post-processing speed and achieve a feasible and efficient medication detector that identifies arbitrarily oriented bounding boxes.
Results: Extensive experiments have demonstrated that rotated YOLO detectors are highly suitable for identifying densely arranged drugs. Six thousand synthetic data and 523 hospital collected images have been taken for training of the network. The mean average precision of the proposed network reaches 0.811 with an inference time of less than 300 ms.
Conclusions: This study provides an accurate and fast drug detection solution for the management of special medications. The proposed rotated YOLO detector outperforms its YOLO counterpart in terms of precision.
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http://dx.doi.org/10.21037/qims-21-1146 | DOI Listing |
J Toxicol Sci
January 2025
Department of Pharmaceutical and Environmental Sciences, Tokyo Metropolitan Institute of Public Health.
In illicit drug markets, the most recently expanding new synthetic opioid subclass is benzimidazoles, also known as nitazenes, which were originally developed as analgesics in the 1950s. The emergence of this classical, potent drug family has attracted extensive research interest in the field of forensic toxicology; however, information on their psychological and physical dependence is very limited. Herein, we evaluated the rewarding effects of four nitazene analogs using a battery of in vivo experiments, with a positive control drug (isotonitazene).
View Article and Find Full Text PDFSci Rep
January 2025
Golestan Research Center of Gastroentrology and Hepatology & Stem Cell Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
Children are highly sensitive to toxins which can damage their organs and lead to death. Investigating the main causes of intoxication could reduce mortality and morbidity in children. In this cross-sectional study, the documents of all poisoned patients (214 cases) admitted to the emergency department of Taleghani children`s Hospital between April 2020 and 2023 were investigated.
View Article and Find Full Text PDFRev Int Androl
December 2024
Department of Human Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, P.O. Box 5001, 435101 Nnewi, AN, Nigeria.
Background: Tramadol, an opioid analgesic, is known to induce testicular damage and impair reproductive parameters. Vitamin D3, recognized for its antioxidant and protective properties, might offer a potential protective effect against tramadol-induced testicular damage. This study observed the effects of co-administration of vitamin D3 and tramadol on serum kisspeptin levels, testicular histology, semen parameters, testosterone levels, and oxidative stress markers in male rats.
View Article and Find Full Text PDFImmunopharmacol Immunotoxicol
February 2025
Pharmacology Department, Medical Research and Clinical Studies Institute, National Research Center, Cairo, Egypt.
Background: Ulcerative colitis (UC) is a frequent inflammatory bowel disease (IBD) that causes long-lasting inflammation in the innermost lining of the rectum and colon.
Objective: The aim of this study was to evaluate the therapeutic effect of () on the amelioration of acetic acid-induced colitis in rats.
Materials And Methods: Group 1: normal control group was intrarectally administered saline solution (0.
Drug Des Devel Ther
December 2024
Department of Anesthesiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, People's Republic of China.
Objective: To evaluate the effect of intravenous lidocaine injection on the half-maximum effective concentration (EC50) of remifentanil in preventing cough due to tracheal extubation in female patients undergoing thyroid surgery by Dixon's sequential method.
Methods: A total of 50 female patients underwent elective thyroidectomy were randomly divided into two groups of a 1:1 ratio. Group L (lidocaine group) was given intravenous lidocaine (1.
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