Several inflammatory diseases are characterized by elevated T cell counts and high pro-inflammatory cytokine levels. Inhibiting T cell activity may reduce tissue damage associated with these diseases. Acthar Gel has potent anti-inflammatory properties, yet little is known about its effect on T cells. This study compared the effects of Acthar, synthetic adrenocorticotropic hormone 1-24 (ACTH) depot, and prednisolone in a murine model of T cell activation. Assessments of CD4 helper and CD8 cytotoxic T cells and plasma concentrations of interferon-γ (IFN-γ), interleukin-2 (IL-2), and tumor necrosis factor-α (TNF-α) were made following anti-CD3-activation. Acthar significantly reduced the number of activated CD4 and CD8 T cells at amounts comparable to synthetic ACTH depot or prednisolone. However, Acthar reduced production of IFN-γ, IL-2, and TNF-α significantly more than the other drugs, suggesting that the immunomodulatory effects of Acthar on T cells are distinct from synthetic ACTH depot or prednisolone.
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| http://dx.doi.org/10.1089/jir.2022.0257 | DOI Listing |
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