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| http://dx.doi.org/10.1111/pbi.14050 | DOI Listing |
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The trait-specific timing of accelerated genomic change in the human lineage.
Cell Genom
January 2025
Department of Integrative Biology, The University of Texas at Austin, Austin, TX, USA; Department of Statistics and Data Science, The University of Texas at Austin, Austin, TX, USA. Electronic address:
Humans exhibit distinct characteristics compared to our primate and ancient hominin ancestors. To investigate genomic bursts in the evolution of these traits, we use two complementary approaches to examine enrichment among genome-wide association study loci spanning diseases and AI-based image-derived brain, heart, and skeletal tissue phenotypes with genomic regions reflecting four evolutionary divergence points. These regions cover epigenetic differences among humans and rhesus macaques, human accelerated regions (HARs), ancient selective sweeps, and Neanderthal-introgressed alleles.
View Article and Find Full Text PDFPalladium-Catalyzed Stereospecific Glycosylation Enables Divergent Synthesis of N-O-Linked Glycosides.
Org Lett
January 2025
Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chemical Biology Research Center, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, People's Republic of China.
We present a versatile palladium-catalyzed glycosylation platform that enables facile access to structurally diverse N-O-linked glycosides with constantly excellent regio- and stereoselectivities. Importantly, this approach offers a broad substrate scope, low catalyst loadings, and outstanding chemoselectivity, allowing for the selective reaction of oximes/hydroximic acids over hydroxyl groups that would otherwise pose challenges in conventional glycosylation methods. The synthetic utility of this method is further exemplified through a range of synthetic transformations and late-stage modification of bioactive molecules.
View Article and Find Full Text PDFIn this study, we performed a comparative analysis based on a total of 255 spider mitogenomes and four outgroups, of which the mitogenomes of 39 species were assembled de novo, to explore the phylogenetic relationships and the adaptive evolution of mitogenomes. Results showed that had the longest mitochondrial length and the most pronounced codon preference to be UUA, followed by CCU. Codon usage frequencies were similar between families and codon usage in the mitogenome of spiders was mainly influenced by natural selection pressures rather than G/C mutation bias.
View Article and Find Full Text PDFMolecular Evolution of Paralogous Cold Shock Proteins in E. coli: A Study of Asymmetric Divergence and Protein Functional Networks.
Mol Biotechnol
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Amity Institute of Biotechnology, Amity University, Kolkata, India.
Nine homologous Cold Shock Proteins (Csps) have been recognized in the E.coli Cold Shock Domain gene family. These Csps function as RNA chaperones.
View Article and Find Full Text PDFFeed efficiency and resilience in dairy ewes subjected to a nutritional challenge.
J Dairy Sci
January 2025
Instituto de Ganadería de Montaña (CSIC-University of León), Finca Marzanas s/n, 24346 Grulleros, León, Spain.
It is currently uncertain how selection of more efficient animals might impact other traits such as resilience (which, in this context, is defined as the ability of an animal to sustain or revert quickly to its previous production level and health status after a disturbance), especially in small ruminants. However, improving, or at least maintaining, resilience is of utmost importance to ensure livestock production in the face of external perturbances, which are expected to become more prevalent in the near future due to climate change and global instability. This study was conducted to investigate whether a nutritional challenge consisting of animals receiving only 70% of their voluntary feed intake (DMI) for 26 d, might differentially affect the response of high- and low-feed efficiency (FE) sheep.
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